TGFβ superfamily signaling in the neural crest lineage
TGFβ superfamily signaling in the neural crest lineage
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DOI：
10.4161/cam.5.3.15498
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发表时间：
2011-05-01
影响因子：
3.2
通讯作者：
Kaartinen, Vesa
中科院分区：
文献类型：
--
作者：
Conway, Simon J.;Kaartinen, Vesa
神经嵴细胞（NCC）谱系通常被称为胚胎中的第四胚层，因为其在整个发育身体中的多种组织和器官系统的广泛迁移和早期定殖令人震惊。许多人类出生缺陷被认为起源于NCC谱系。最近令人兴奋的条件性小鼠靶向和转基因组合抑制方法已经揭示了TGF β超家族是心脏和颅NCC亚群中的关键信号传导途径。鉴于TGF β超家族信号传导的复杂性，以及多个配体和受体组合已被证明在NCC亚群内表达，以及转基因靶向整个信号级联的困难，我们回顾了几种最新的转基因方法，揭示了意想不到的后果。
The neural crest cell (NCC) lineage is often referred to as the fourth germ layer in embryos, as its wide range of migration and early colonization of multiple tissues and organ systems throughout the developing body is astounding. Many human birth defects are thought to have their origins within the NCC lineage. Exciting recent conditional mouse targeting and transgenic combinatorial suppression approaches have revealed that the TGF beta superfamily is a key signaling pathway within the cardiac and cranial NCC subpopulations. Given the complexity of TGF beta superfamily signaling and that multiple ligand and receptor combinations have already been shown to be expressed within the NCC subpopulations, and the difficulty in transgenically targeting entire signaling cascades, we review several up-to-date transgenic approaches that are revealing unexpected consequences.