A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system.
A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system.
复制标题
用于胸膜光动力治疗的实时红外导航系统，具有 3D 表面采集系统。
DOI：
10.1117/12.2650456
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhu,TimothyC
中科院分区：
文献类型：
--
作者：
Sun,Hongjing;Sourvanos,Dennis;Potasek,Mary;Parilov,Gene;Beesonk,Carl;Zhu,TimothyC
光动力疗法（PDT）已被用于手术治疗恶性胸膜间皮瘤患者。对于PDT的效率，均匀地递送光剂量是至关重要的。目前的手术利用放置在胸膜腔内的八个光探测器来监测光。一个更新的导航系统，结合一种新的扫描系统，开发胸膜PDT过程中为医生提供实时指导，以改善光传输。扫描系统由两个手持式三维（3D）扫描仪组成，用于在PDT之前快速准确地捕获胸膜腔的表面形貌，以便在PDT期间识别目标表面以进行实时光通量分布计算。开发了一种算法来进一步处理扫描体积以进行降噪以进行精确的光通量计算，并将局部坐标系旋转到任何期望的方向以在实时引导期间实现清晰的可视化。利用至少三个标记将导航坐标系配准到患者坐标系，以在整个治疗过程中跟踪胸膜腔内的光源点位置。在PDT期间，光源位置、扫描的胸膜腔和腔表面的光通量分布将分别以3D和2D显示。为了进行验证，使用基于个人CT扫描的不同体积的大型胸部模型和3D打印肺模型的模型研究来测试这种新型系统，浸入具有不同光学特性的液体组织模拟模型中，并用八个各向同性探测器和导航系统进行处理。
Photodynamic therapy (PDT) has been used intraoperatively to treat patients with malignant pleural mesothelioma. For the efficiency of PDT, it is crucial to deliver light doses uniformly. The current procedure utilizes eight light detectors placed inside the pleural cavity to monitor the light. An updated navigation system, combined with a novel scanning system, is developed to provide real-time guidance for physicians during pleural PDT to improve light delivery. The scanning system consists of two handheld three-dimensional (3D) scanners to capture the pleural cavity's surface topographies quickly and precisely before PDT so that the target surface can be identified for real-time light fluence distribution calculation during PDT. An algorithm is developed to further process the scanned volume to denoise for accurate light fluence calculation and rotate the local coordinate system into any desired direction for a clear visualization during the real-time guidance. The navigation coordinate system is registered to the patient coordinate system utilizing at least three markers to track the light source point position within the pleural cavity throughout the treatment. During PDT, the light source position, the scanned pleural cavity, and the light fluence distribution for the cavity's surface will be displayed in 3D and 2D, respectively. For validation, this novel system is tested using phantom studies with a large chest phantom and 3D-printed lung phantoms of different volumes based on a personal CT scan, immersed in a liquid tissue-simulating phantom with different optical properties, and treated with eight isotropic detectors and the navigation system.