ACUTE CHEST SYNDROME IN ADULTS WITH SICKLE-CELL ANEMIA - MICROBIOLOGY, TREATMENT, AND PREVENTION
ACUTE CHEST SYNDROME IN ADULTS WITH SICKLE-CELL ANEMIA - MICROBIOLOGY, TREATMENT, AND PREVENTION
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DOI：
10.1001/archinte.139.1.67
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
CHARACHE, P
中科院分区：
文献类型：
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作者：
CHARACHE, S;SCOTT, JC;CHARACHE, P
研究了28例成人镰状细胞性贫血患者的发热、胸痛、白细胞增多和肺浸润（“急性胸部综合征”）。在不到一半的病例的痰培养中确定了可能的细菌病原体;未发现肺炎球菌，金黄色葡萄球菌是唯一与仅恢复正常植物群时观察到的疾病时间更长相关的细菌。在患有镰状细胞性贫血的成人中，许多被诊断为肺炎的疾病可能是肺梗死。这些患者中的许多人只需适度的支持治疗就可以康复;如果使用抗生素，它们应该针对S。金黄色葡萄球菌（可能还有嗜血杆菌属）。肺炎球菌多糖疫苗在预防镰状细胞性贫血儿童危及生命的感染方面具有很大的潜力，但可能不会改变成人急性胸部综合征的发病率或严重程度。
Episodes (52) of fever, chest pain, increased leukocytosis and pulmonary infiltrate (''acute chest syndrome'') were studied in 28 adults with sickle cell anemia. Possible bacterial pathogens were identified in sputum cultures from less than half of the episodes; no pneumococci were found and Staphylococcus aureus was the only bacterium associated with a longer illness than that seen when only normal flora were recovered. Much disease diagnosed as pneumonia in adults with sickle cell anemia is probably pulmonary infarction. Many of these patients will recover with no more than modest supportive care; if antibiotics are used they should be directed against S. aureus (and possibly Haemophilus spp.). Pneumococcal polysaccharide vaccine has great potential for preventing life-threatening infection in children with sickle cell anemia, but may not change the incidence or severity of the acute chest syndrome in adults.