The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p)
The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p)
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DOI：
10.1038/sj.gt.3302736
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发表时间：
2006-06-01
期刊：
影响因子：
5.1
通讯作者：
Hermiston, T. W.
中科院分区：
文献类型：
--
作者：
Shen, B. H.;Bauzon, M.;Hermiston, T. W.
正在测试复制的肿瘤选择性病毒作为人类癌症的潜在治疗方法。缺氧是一种病理生理癌症状况，其通过不依赖于受体水平或内化速率的机制改变有复制能力的腺病毒血清型5（Ad 5）病毒的裂解潜力。我们将这些初步研究扩展到检测缺氧对B组腺病毒（Ads）、3型腺病毒（Ad 3）（B1组）和11 p型腺病毒（Ad 11 p）（B2组）的潜在影响。受体表达（CD 46）不受缺氧的影响。然而，裂解潜力以细胞依赖性方式受损。因此，我们的研究表明，B组复制的基于Ad的治疗，如C组Ad-5的病毒，将需要进行修改，以有效地治疗人类肿瘤的缺氧成分。
Replicating, tumor selective viruses are being tested as potential treatments for human cancers. Hypoxia is a pathophysiological cancer condition that alters the lytic potential of the replication-competent adenovirus serotype 5 (Ad5) virus by a mechanism independent of receptor l evels or internalization rates. We extend these initial studies to examine the potential effects of hypoxia on the group B adenoviruses (Ads), adenovirus type 3 (Ad3) (group B1) and adenovirus type 11p (Ad11p) ( group B2). Receptor expression (CD46) is not altered by hypoxia. However, the lytic potential is compromised in a cell-dependent fashion. Consequently, our study suggests that group B replicating Ad-based treatments, like the group C Ad-5-based viruses, will need to be modified in order to effectively treat hypoxic components of human tumors.