Integrin expression by human articular chondrocytes.
Integrin expression by human articular chondrocytes.
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DOI：
10.1093/rheumatology/31.4.231
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发表时间：
1992-04
期刊：
影响因子：
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通讯作者：
Donald Salter;D. Hughes;R. Simpson;D. Gardner
中科院分区：
文献类型：
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作者：
Donald Salter;D. Hughes;R. Simpson;D. Gardner
整合素，一个家庭的细胞粘附蛋白，在体内的人关节软骨软骨细胞的表达已经研究了免疫组织学技术，使用低温切片和一组抗整合素单克隆抗体。软骨细胞强烈表达β 1和α 5整合素亚基，已知这些亚基强烈形成经典的纤连蛋白受体VLA-5。α 1表达较弱，α 3仅由偶见细胞表达。软骨细胞不表达β 2、β 3或其他测试的整合素α亚基。
Expression of integrins, a family of cell adhesion proteins, by human articular cartilage chondrocytes in vivo has been studied by immunohistological techniques using cryostat sections and a panel of anti-integrin monoclonal antibodies. Chondrocytes strongly expressed beta 1 and alpha 5 integrin subunits, known to form the classical fibronectin receptor, VLA-5, strongly. alpha 1 was expressed more weakly and variably; alpha 3 was expressed by occasional cells only. Chondrocytes did not express beta 2, beta 3 or other integrin alpha subunits tested.