Allergic adverse transfusion reactions in paediatrics, a 3-year study
Allergic adverse transfusion reactions in paediatrics, a 3-year study
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DOI：
10.1016/j.tracli.2013.09.002
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发表时间：
2013-12-01
影响因子：
1.7
通讯作者：
Meyer, F.
中科院分区：
文献类型：
--
作者：
Moncharmont, P.;Meyer, F.
研究目的：2011年法国输血患者中，过敏排在输血不良反应的第三位。为了评估儿科人群过敏性输血不良反应的发生率和症状学，进行了一项研究。患者和方法。它的重点是在罗纳-阿尔卑斯地区医院接受治疗的18岁以下患者。回顾了国家血液警戒数据库（e-FIT）中有关过敏性输血反应的报告。2009年1月1日至2011年12月31日，在2165份报告中，收集儿科患者输血不良反应报告141份（6.5%）。68例（48.2%）有过敏反应，对应64例接受者。临床表现方面，仅有皮肤征象48例（70.6%），仅有肺征象3例（4.4%），两者均有9例（13.2%）。荨麻疹38例（55.9%）。支气管痉挛4例，无血管性水肿。反应严重程度方面，1例输血不良反应严重（2级），2例危及生命（3级）。血液成分以单采血小板浓缩液最多（40例，58.8%），其次是红细胞浓缩液（17例，25.0%）和亚甲基蓝处理的新鲜冷冻血浆（11例，16.2%）。本研究表明，在儿科受者中，皮肤症状在过敏性输血不良反应中占主导地位，血浆浓缩血小板是最常涉及的血液成分。(C) 2013 Elsevier Masson SAS。版权所有。
Purpose of the study. In the transfused patients, in France, in 2011, allergy ranked as the third adverse transfusion reaction. In order to evaluate the incidence and symptomatology of allergic adverse transfusion reactions in the paediatric people, a study was performed.Patients and methods. It was focused on patients under 18 years of age cared for in hospitals of the Rhone-Alpes area. The national haemovigilance database (e-FIT) reports of allergic transfusion reactions were reviewed.Results. From January 1st 2009 to December 31st 2011, among 2,165 reports, 141 (6.5%) adverse transfusion reaction reports were collected in paediatric patients. Sixty-eight (48.2%) indicated allergic reactions and corresponded to 64 recipients. As regards clinical manifestations, forty-eight (70.6%) indicated cutaneous signs only, 3 (4.4%) mentioned pulmonary signs only and 9 (13.2%) reported both. Urticaria was observed in 38 cases (55.9%). Bronchospasm was notified in 4 cases but there was no angioedema. As for the severity of reactions, one adverse transfusion reaction was severe (grade 2) and 2 were life-threatening (grade 3). The most involved blood component was the apheresis platelet concentrate (40 cases, 58.8%) followed by the red blood cell concentrate (17 cases, 25.0%) and the methylene blue-treated fresh-frozen plasma (11 cases, 16.2%).Conclusion. This study shows that among paediatric recipients, cutaneous signs are predominant in allergic adverse transfusion reactions and that the apheresis platelet concentrate is the most frequently involved blood component. (C) 2013 Elsevier Masson SAS. All rights reserved.