Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans -[Ru(NHC) 4 H 2 ] through a Concerted Nucleophilic Ru-H Attack Pathway
Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans -[Ru(NHC) 4 H 2 ] through a Concerted Nucleophilic Ru-H Attack Pathway
复制标题
通过协同亲核 Ru-H 攻击途径，用反式 -[Ru(NHC) 4 H 2 ] 进行氟芳烃的室温区域选择性催化加氢脱氟反应
DOI：
10.1002/ange.201610820
复制
发表时间：
2017
影响因子：
--
通讯作者：
Cybulski M
中科院分区：
文献类型：
--
作者：
Cybulski M
报道了反式[Ru(IMe4)4H2]催化剂3对氟芳烃进行了高效、高选择性的室温加氢脱氟反应。机理研究表明，3直接作用于催化，没有任何配体解离，DFT计算表明一个协调的亲核攻击机制。计算充分说明了观察到的选择性，证实了早先关于HDF选择性的预测。
The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans‐[Ru(IMe4)4H2] catalyst,3, is reported. Mechanistic studies show3acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.