Insulin control of cyclic AMP phosphodiesterase.
Insulin control of cyclic AMP phosphodiesterase.
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环AMP磷酸二酯酶的胰岛素控制。
DOI：
10.1016/0024-3205(89)90067-2
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发表时间：
1989
期刊：
影响因子：
6.1
通讯作者：
Solomon,SS
中科院分区：
文献类型：
--
作者：
Smoake,JA;Solomon,SS
环AMP磷酸二酯酶（PDE）是参与环AMP的细胞内稳态的酶。它在细胞中以多种同工酶的形式存在，但只有高亲和力的膜结合同工酶对激素调节敏感。已检测到低KmPDE的几种同工酶或同工型。数据表明，PDE的激素调节存在几种机制。低KmPDE种类的活性可通过磷酸化/去磷酸化、磷脂底物浓度、胰岛素第二信使、环GMP、鸟嘌呤核苷酸结合蛋白、钙调蛋白或单体形式的聚集/解聚来调节。不同激素对PDE亚型的调节可能是通过不同的调节组分或机制。
Cyclic AMP phosphodiesterase (PDE) is an enzyme involved in cellular homeostasis of cyclic AMP. It exists as multiple isozymes in cells, but only the high affinity, membrane-bound isozyme is sensitive to hormonal modulation. Several isozymes or isoforms of the low KmPDE have been detected. Data suggest that several mechanisms exist for hormonal modulation of PDE. Activity of the low KmPDE species may be modulated by phosphorylation/dephosphorylation, phospholipid substrate concentration, insulin second messenger, cyclic GMP, guanine nucleotide binding proteins, calmodulin, or aggregation/ disaggregation of monomeric forms. Modulation of PDE isoforms by different hormones may be through different regulatory components or mechanisms.