Spatial low frequency pattern analysis in positron emission tomography: a study between normals and schizophrenics.
Spatial low frequency pattern analysis in positron emission tomography: a study between normals and schizophrenics.
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发表时间：
1992-02
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通讯作者：
A. Levy;F. Gómez-Mont;N. Volkow;Juan F. Corona;J. Brodie;R. Cancro
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作者：
A. Levy;F. Gómez-Mont;N. Volkow;Juan F. Corona;J. Brodie;R. Cancro
使用二维傅立叶变换和大脑的质心主轴，开发了一种方法，用于分析PET代谢脑图像，而不使用预定义的解剖区域的利益。我们应用的方法，从一组11个正常和12个药物治疗精神分裂症患者在休息条件下，根据视觉任务的图像。皮质/皮质下空间模式被认为是显着的两个方向：前/后和交叉（左前/右后）。最好的个体临床分类（Jackknife分类）发生在视觉任务下的两个轴向脑水平：在基底节，正确分类率为91%和84%，而小脑的正确分类率为82%和92%。这些高的分类率仅使用最低空间频率的四个系数获得。这些结果表明，在休息和视觉图像跟踪任务中，慢性药物治疗精神分裂症患者的局部葡萄糖代谢普遍存在脑功能障碍。
Using the two-dimensional Fourier transform and the brain's centroidal principal axis, a method is developed for the analysis of PET metabolic brain images without the use of predefined anatomic regions of interest. We applied the method to images from a group of 11 normal and 12 medicated schizophrenics tested under resting conditions and under a visual task. A cortical/subcortical spatial pattern was found to be significant in two directions; anterior/posterior and chiasmatic (left-anterior/right-posterior). The best individual clinical classification (Jackknife classification) occurred under visual task at two axial brain levels: at the basal ganglia with correct classification rates of 91% and 84%, while the cerebellum had rates of 82% and 92%. These high classification rates were obtained using only the four coefficients of the lowest spatial frequency. These results point to the generalized brain dysfunction of regional glucose metabolism in chronic medicated schizophrenics both at rest and at a visual image-tracking task.