X-irradiation-induced loss of O-2A progenitor cells in rat spinal cord is inhibited by implants of cells engineered to secrete glial growth factor 2.
X-irradiation-induced loss of O-2A progenitor cells in rat spinal cord is inhibited by implants of cells engineered to secrete glial growth factor 2.
复制标题
X 射线照射引起的大鼠脊髓中 O-2A 祖细胞的损失可以通过植入经过改造的细胞来分泌神经胶质生长因子 2 来抑制。
DOI：
10.1097/00001756-199902250-00017
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Tofilon,PJ
中科院分区：
文献类型：
--
作者：
Noel,F;Raju,U;Happel,E;Marchionni,MA;Tofilon,PJ
THE loss of O-2A progenitor cells has been implicated as a critical event in radiation-induced spinal cord demyelination. To investigate whether glial growth factor 2 (GGF2) affects the number of O-2A cells in the irradiated rat cervical spinal cord, an ex vivo gene therapy approach was applied in which CHO cells engineered to express recombinant human GGF2 were injected into the cisterna magna of adult rats. Spinal cord irradiation reduced the number of O-2A cells in a dose-dependent manner. However, this radiation-induced decrease in O-2A progenitor cells was significantly attenuated by the delivery of GGF2 after irradiation. These data indicate that the cell-mediated delivery of GGF2 can reduce the loss of O-2A progenitors after irradiation.
