MATERNAL HORMONE LEVELS IN EARLY GESTATION OF CRYPTORCHID MALES - A CASE-CONTROL STUDY
MATERNAL HORMONE LEVELS IN EARLY GESTATION OF CRYPTORCHID MALES - A CASE-CONTROL STUDY
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DOI：
10.1038/bjc.1988.223
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发表时间：
1988-09-01
影响因子：
8.8
通讯作者：
HENDERSON, BE
中科院分区：
文献类型：
--
作者：
BERNSTEIN, L;PIKE, MC;HENDERSON, BE
进行了一项病例对照研究，以评估与生育隐睾儿子风险增加相关的母体激素因素。血清样本是在美国合作围产期研究的参与者怀孕的前三个月收集的。25名正常子女的母亲（对照）分别在抽样时的医疗中心、年龄、胎次、体重和妊娠长度与一岁或更大的隐睾诊断的儿子的妇女相匹配。与对照组相比，隐睾儿（例）的母亲在指数妊娠的前三个月的非蛋白结合（P = 0.010）和白蛋白结合（P = 0.014）雌二醇的百分比显著高于对照组。平均而言，实验组的生物可利用雌二醇含量比对照组高16%。人绒毛膜促性腺激素、睾酮、非蛋白结合睾酮和性激素结合球蛋白的水平在两组之间没有差异。这些数据支持了隐睾症是由妊娠早期母体雌激素水平升高引起的假说。
A case-control study was conducted to assess maternal hormonal factors associated with increased risk of bearing a cryptorchid son. Serum samples were collected during the first trimester of pregnancy from participants in the US Collaborative Perinatal Study. Twenty-five mothers of normal offspring (controls) were individually matched on medical center, age, parity, weight and length of gestation at the time of sampling to women bearing sons who had a diagnosis of cryptorchidism at one year of age or older. Compared with controls, mothers of cryptorchid sons (cases) had significantly greater percentages of non-protein bound (P = 0.010) and albumin-bound (P = 0.014) estradiol during the first trimester of the index pregnancy. On average, cases had 16% more bioavailable oestradiol than controls. Levels of human chorionic gonadotropin, testosterone, non-protein bound testosterone and sex-hormone binding globulin did not differ between the two groups. The data presented support the hypothesis that cryptorchidism results from elevated maternal oestrogen levels early in pregnancy.