Why and how to expand the role of systems biology in pharmaceutical research and development.
Why and how to expand the role of systems biology in pharmaceutical research and development.
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DOI：
10.1007/978-1-4419-7210-1_31
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发表时间：
2012
影响因子：
--
通讯作者：
R. Phair
中科院分区：
文献类型：
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作者：
R. Phair
从资助机构、投资者和公众的角度来看，尽管投资增加，但我们全球生物医学研究企业的生产率正在下降。这篇评论文章提出了一个原因和解决方案。原因是人类生物学和病理生理学的巨大复杂性。尚未解决的人类疾病涉及如此多的相互作用的变量，以至于由熟练的主要研究人员领导的单一研究实验室进行创新的实验工作，不能指望将还原论者的碎片组装成一个完整的工作模型。系统生物学提供了一个解决方案，但它需要团队合作。由实验和计算生物学家组成的平等团队可以构建多尺度微分方程模型，并根据实验数据对其进行测试。一个成功的模型为整个研发团队提供了可操作的循证指导。由于历史和文化的原因，这些综合生物学团队在学术界可能是不可持续的，但它们似乎自然适合现代制药研究和开发。组织这样的团队和他们的工作流程的一种方式进行了详细描述。
Seen from the perspective of funding organizations, investors, and the general public, the productivity of our world-wide biomedical research enterprise is declining despite increased investment. This opinion piece suggests a cause and a solution. The cause is the enormous complexity of human biology and pathophysiology. The unsolved human diseases involve so many interacting variables that single research laboratories headed by skilled principal investigators doing innovative experimental work cannot be expected to assemble the reductionist pieces into an integrated working model. Systems biology offers a solution, but it will require teamwork. Co-equal teams of experimental and computational biologists can construct multiscale differential equation models and test them against experimental data. A successful model provides actionable evidence-based guidance to the entire research and development team. These integrative biology teams may, for historical and cultural reasons, be unsustainable in academia, but they seem naturally suited to modern pharmaceutical research and development. One way to organize such teams and their workflow is described in detail.