Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle
Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle
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DOI：
10.1038/ncomms1840
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发表时间：
2012-05-01
影响因子：
16.6
通讯作者：
Williams, Diana J. L.
中科院分区：
文献类型：
--
作者：
Claridge, Jen;Diggle, Peter;Williams, Diana J. L.
牛结核病（Bovine tuberculosis，BTB）是由牛分枝杆菌（Mycobacterium bovis）引起的一种重要而难治的疾病。在联合王国，尽管实施了积极的根除方案，但BTB的流行率仍在上升，病例数逐年呈指数级上升，原因不明。在这里，我们在一项涉及英格兰和威尔士3,026个奶牛群的研究中表明，暴露于常见的、无处不在的蠕虫寄生虫肝片吸虫与BTB的诊断之间存在显著的负相关。用于诊断BTB的单次皮内比较颈部结核菌素试验的量值在实验性合并感染M的牛中降低。bovis和F.肝。我们估计，在我们的研究农场中，在没有暴露于F的假设情况下，不确定率约为三分之一（95%置信区间27-38%）。肝。这一发现可能部分解释了BTB的持续传播以及联合王国目前根除计划的失败。
Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication programme, the prevalence of BTB is increasing with an unexplained, exponential rise in cases year on year. Here we show in a study involving 3,026 dairy herds in England and Wales that there is a significant negative association between exposure to the common, ubiquitous helminth parasite, Fasciola hepatica and diagnosis of BTB. The magnitude of the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattle experimentally co-infected with M. bovis and F. hepatica. We estimate an under-ascertainment rate of about one-third (95% confidence interval 27-38%) among our study farms, in the hypothetical situation of no exposure to F. hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom.