Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina.
Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina.
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DOI：
10.3390/ijerph182211824
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发表时间：
2021-11-11
影响因子：
--
通讯作者：
Halbert CH
中科院分区：
文献类型：
--
作者：
Babatunde OA;Zahnd WE;Eberth JM;Lawson AB;Adams SA;Boakye EA;Jefferson MS;Allen CG;Pearce JL;Li H;Halbert CH
本研究的目的是检查非裔美国人和白人乳腺癌患者的社区社会剥夺与乳腺癌分期的个体特征之间的关联。我们利用南卡罗来纳州中央癌症登记处建立了 1996 年至 2015 年诊断的乳腺癌患者的回顾性队列。我们从登记中提取了社会人口统计学和临床变量，并将这些数据与捕捉社区社会状况的县级综合数据——社会剥夺指数（SDI）联系起来。使用卡方检验、学生 t 检验和多变量序数回归分析来分析数据以评估关联性。研究样本包括 52,803 名女性乳腺癌患者。多变量序数回归模型的结果表明，较高的 SDI（OR = 1.06，95% CI：1.02–1.10）、非裔美国人种族（OR = 1.35，95% CI：1.29–1.41）和未婚（OR = 1.17，95% CI：1.13–1.22）与诊断时的分期较远相关。较高的肿瘤分级、较年轻的年龄和较近的诊断年份也与远期诊断相关。作为邻里环境的代表，癌症登记处和相关的基于人群的研究可以使用 SDI 来确定可以优先进行癌症预防和控制工作的地理区域。
The purpose of this study was to examine the association between neighborhood social deprivation and individual-level characteristics on breast cancer staging in African American and white breast cancer patients. We established a retrospective cohort of patients with breast cancer diagnosed from 1996 to 2015 using the South Carolina Central Cancer Registry. We abstracted sociodemographic and clinical variables from the registry and linked these data to a county-level composite that captured neighborhood social conditions—the social deprivation index (SDI). Data were analyzed using chi-square tests, Student’s t-test, and multivariable ordinal regression analysis to evaluate associations. The study sample included 52,803 female patients with breast cancer. Results from the multivariable ordinal regression model demonstrate that higher SDI (OR = 1.06, 95% CI: 1.02–1.10), African American race (OR = 1.35, 95% CI: 1.29–1.41), and being unmarried (OR = 1.17, 95% CI: 1.13–1.22) were associated with a distant stage at diagnosis. Higher tumor grade, younger age, and more recent year of diagnosis were also associated with distant-stage diagnosis. As a proxy for neighborhood context, the SDI can be used by cancer registries and related population-based studies to identify geographic areas that could be prioritized for cancer prevention and control efforts.
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影响因子：
3.2
作者：
Brill, Joel, V
通讯作者：
Brill, Joel, V
影响因子：
3.9
作者：
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通讯作者：
Thompson E
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Chauvin, Franck
影响因子：
4.9
作者：
Weis, Kristina E.;Liese, Angela D.;Duffus, Wayne A.
通讯作者：
Duffus, Wayne A.