Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK
Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK
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DOI：
10.1080/19440049.2010.551301
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Turner, P. C.
中科院分区：
文献类型：
--
作者：
Hepworth, S. J.;Hardie, L. J.;Turner, P. C.
脱氧雪腐镰刀菌烯醇（DON）是世界温带地区普遍存在的谷类作物污染物。它会导致动物生长迟缓和免疫抑制。关于英国亚群DON暴露的信息有限。本研究的目的是在英国布拉德福德的一个大型多种族母亲/婴儿出生队列中，对计划进行择期剖腹产的孕妇子集进行DON暴露评估。年龄在16-44岁之间的妇女（n = 85）在妊娠的最后三个月提供了用于DON分析的尿液样本，并同时完成了食物频率问卷（FFQ）。在所有测量的样品中检测到尿DON生物标志物（几何平均值（GM）= 10.3ng DON mg（-1）肌酸酐，范围= 0.5- 116.7ng mg（-1））。与非南亚人（GM = 8.6 ng mg（-1）; 95% CI = 6.6-11.8 ng mg（-1），p = 0.02）相比，南亚裔女性的水平更高（GM：15.2 ng mg（-1）; 95% CI = 10.7-21.5 ng mg（-1））。根据FFQ数据估计的DON摄入量和食物中DON污染的典型水平表明，这主要是由于面包暴露水平较高，特别是南亚人每天从薄饼中摄入的DON（估计平均值= 2.4 μ g/天（-1）; 95% CI = 1.2，3.7 μ g/天（-1））与非南亚人相比（估计平均值= 0.2 μ g/天（-1）; 95% CI = 0-0.4 μ g/天（-1）），p
Deoxynivalenol (DON) is a ubiquitous contaminant of cereal crops in temperate regions of the world. It causes growth faltering and immune suppression in animals. Limited information is available on DON exposure in UK subpopulations. The objective of this study was to provide DON exposure assessment in a subset of pregnant women scheduled for an elective caesarean in a large multi-ethnic mother/infant birth cohort from Bradford, UK. Women aged 16-44 years (n = 85) provided a urine sample for DON analysis in the last trimester of pregnancy, and concurrently completed a food-frequency questionnaire (FFQ). The urinary DON biomarker was detected in all measured samples (geometric mean (GM) = 10.3 ng DON mg(-1) creatinine, range = 0.5-116.7 ng mg(-1)). Levels were higher in women classified as South Asian in origin (GM: 15.2 ng mg(-1); 95% CI = 10.7-21.5 ng mg(-1)) compared with non-South Asians (GM = 8.6 ng mg(-1); 95% CI = 6.6-11.8 ng mg(-1)), p = 0.02). Estimated DON intake from FFQ data and typical levels of DON contamination of food suggest that this was mainly due to higher levels of exposure from bread, particularly daily intake of DON from chapattis in South Asians (estimated mean = 2.4 mu g day(-1); 95% CI = 1.2, 3.7 mu g day(-1)) compared with non-South Asians (estimated mean = 0.2 mu g day(-1); 95% CI = 0-0.4 mu g day(-1)), p