A trial design that generates only "positive" results
A trial design that generates only "positive" results
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DOI：
10.4103/0022-3859.41806
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发表时间：
2008-07-01
影响因子：
1.6
通讯作者：
Lee, M. S.
中科院分区：
文献类型：
--
作者：
Ernst, E.;Lee, M. S.
在这篇文章中，我们测试了这样一种假设，即具有某些设计特征的针灸治疗疼痛的随机临床试验(A+B与B)可能产生假阳性结果。基于对6个数据库的电子搜索，发现13项研究符合我们的纳入标准。他们都认为针灸是有效的(只有一个趋势是积极的，其他的都有显著的效果)。我们得出‘A+B对B’的设计容易出现假阳性结果的结论，并讨论了可能防止或加剧这一问题的设计特征。
In this article, we test the hypothesis that randomized clinical trials of acupuncture for pain with certain design features (A + B versus B) are likely to generate false positive results. Based on electronic searches in six databases, 13 studies were found that met our inclusion criteria. They all suggested that acupuncture is effected (one only showing a positive trend, all others had significant results). We conclude that the 'A + B versus B' design is prone to false positive results and discuss the design features that might prevent or exacerbate this problem.