BLOCKADE OF THE PRESSOR-RESPONSE TO MUSCLE ISCHEMIA BY SENSORY NERVE BLOCK IN MAN
BLOCKADE OF THE PRESSOR-RESPONSE TO MUSCLE ISCHEMIA BY SENSORY NERVE BLOCK IN MAN
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DOI：
10.1152/ajpheart.1979.237.4.h433
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
BUTLER, SH
中科院分区：
文献类型：
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作者：
FREUND, PR;ROWELL, LB;BUTLER, SH
使用区分神经阻滞和硬膜外麻醉来确定人体对肌肉缺血的升压反应是否由刺激细小感觉神经纤维引起，以及这些感觉神经纤维是否参与动态运动中的心血管-呼吸反应。4名男子在50~100W的功率下运动5min。从运动结束前30 S开始，持续运动3min，双腿全循环阻断，造成肌肉缺血和持续性升压反应。在完全运动和感觉阻滞恢复过程中，感觉阻滞持续时运动强度恢复，只要感觉麻醉持续，升压反应即被阻断(2例)。在阻断升压反应的过程中，对运动的心血管-呼吸反应逐渐从增强的水平恢复到正常(阻断前)水平。2名受试者感觉阻断不完全，升压反应未完全阻断。显然，在缺血期间刺激小感觉神经纤维会引起升压反应，但在有足够血流量的温和动态运动中，这些纤维似乎不会对心血管-呼吸反应起作用。
Differential nerve block from peridural anesthesia was used to determine if the pressor response to muscle ischemia in man is caused by stimulation of small sensory nerve fibers and if these fibers contribute to cardiovascular-respiratory responses during dynamic exercise. Four men exercised at 50-100 W for 5 min. Muscle ischemia and a sustained pressor response were produced by total circulatory occlusion of both legs beginning 30 s before the end of exercise and continuing for 3 min postexercise. During regression of full motor and sensory block, motor strength recovered while sensory block continued, the pressor response was blocked as long as sensory anesthesia persisted (2 subjects). During blockade of the pressor response, cardiovascular-respiratory responses to exercise gradually returned from augmented to normal (preblock) levels. Sensory blockade was incomplete in 2 subjects and the pressor response was not fully blocked. Apparently, stimulation of small sensory fibers during ischemia elicits the pressor response, but the fibers appear not to contribute to cardiovascular-respiratory responses during mild dynamic exercise with adequate blood flow.