Effects of extremes of respiratory and metabolic alkalosis on cerebral blood flow in man.
Effects of extremes of respiratory and metabolic alkalosis on cerebral blood flow in man.
复制标题
极端呼吸性碱中毒和代谢性碱中毒对人类脑血流量的影响。
DOI：
10.1152/jappl.1968.24.1.60
复制
发表时间：
1968
影响因子：
3.3
通讯作者：
S. Alexander
中科院分区：
文献类型：
--
作者：
H. Wollman;T. C. Smith;G. Stephen;E. T. Colton;H. E. Gleaton;S. Alexander
方法受试者和麻醉技术。研究对象是 18 名健康男性志愿者，年龄从 2 岁到 1 岁到 31 岁不等。通过在初步访谈中充分解释研究的程序和目的，确保知情同意。在第二次访谈中获得了签署同意书，当时采集了完整的病史并进行了体检。研究当天，至少 24 小时未吸烟的禁食受试者接受 0.6 毫克阿托品肌注。 30分钟后静脉注射2.5mg/kg硫喷妥钠诱导麻醉，然后吸入70%N20-30%Oz。分次静脉内给予足够的d-筒箭毒碱以维持呼吸肌麻痹。整个研究所需的平均剂量为 140 mg（se 6 mg）。气管插管后，用带有麻醉附件的容量有限的 Bird 呼吸器控制通气。非再呼吸回路利用 &lcKesson 麻醉机的 Nargraff 头作为混合阀和 Frumin 阀来防止再呼吸。
METHODSSubjects and anesthetic technique. Eighteen healthy male volunteers, ranging in age from 2 1 to 31 years, were studied. Informed consent was insured by fully explaining the procedures and purposes of the study in a preliminary intcrvicw. Signed consent was obtained at a second interview, when a complete history was taken and a physical examination performed. On the day of the study, fasting subjects who had not smoked for at least 24 hr received 0.6 mg atropine intramuscularly. Anesthesia was induced 30 min later with 2.5 mg/kg of thiopental intravenously, followed by the inhalation of 70% N20-30% Oz. Sufficient d-tubocurarine was administered intravenously in divided doses to maintain paralysis of the respiratory muscles. The average dose required for the entire study was 140 mg (se 6 mg). Following tracheal intubation, ventilation was controlled with a volume-limited Bird respirator with anesthesia attachment. A nonrebreathing circuit utilized the Nargraff head of a &lcKesson anesthesia machine as a mixing valve and a Frumin valve to prevent rebreathing.