Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?
Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?
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DOI：
10.1016/j.preteyeres.2013.06.003
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发表时间：
2013-09
影响因子：
17.8
通讯作者：
Carr DJ
中科院分区：
文献类型：
--
作者：
Bryant-Hudson K;Conrady CD;Carr DJ
1型单纯疱疹病毒（HSV-1）是一种非常成功的病原体，可导致显著的人类发病率。在角膜内，人们认为病原体的最初识别是通过在常驻细胞上表达的toll样受体，然后引发促炎细胞因子的产生，抗病毒途径的激活和白细胞的募集。然而，我们的实验室发现了一种新的、不依赖TLR的先天传感器，它取代了HSV-1感染后TLR诱导的抗病毒途径。此外，我们还发现HSV-1通过一种独立于tlr的机制诱导淋巴管进入角膜，这在新生血管领域是独一无二的。本文将对急性单纯疱疹-1型角膜感染期间的这两种先天性免疫事件进行综述。
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that can result in significant human morbidity. Within the cornea, it was thought the initial recognition of the pathogen was through Toll-like receptors expressed on/in resident cells that then elicit pro-inflammatory cytokine production, activation of anti-viral pathways, and recruitment of leukocytes. However, our lab has uncovered a novel, TLR-independent innate sensor that supersedes TLR induction of anti-viral pathways following HSV-1 infection. In addition, we have also found HSV-1 induces the genesis of lymphatic vessels into the cornea proper by a mechanism independent of TLRs and unique in the field of neovascularization. This review will focus on these two innate immune events during acute HSV-1 infection of the cornea.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Conrady, Christopher D.;Halford, William P.;Carr, Daniel J. J.
通讯作者：
Carr, Daniel J. J.
影响因子：
7
作者：
Barber GN
通讯作者：
Barber GN
影响因子：
2.8
作者：
Cursiefen, C;Maruyama, K;Kruse, FE
通讯作者：
Kruse, FE
影响因子：
4.4
作者：
Conrady, Christopher D.;Thapa, Manoj;Carr, Daniel J. J.
通讯作者：
Carr, Daniel J. J.