A reevaluation of the role of the lateral hypothalamus in behavioral temperature regulation.
A reevaluation of the role of the lateral hypothalamus in behavioral temperature regulation.
复制标题
重新评估下丘脑外侧在行为温度调节中的作用。
DOI：
10.1016/0031-9384(87)90206-x
复制
发表时间：
1987
影响因子：
2.9
通讯作者：
Carlisle,HJ
中科院分区：
文献类型：
--
作者：
Refinetti,R;Carlisle,HJ
暴露在寒冷（-9 °C）中的大鼠被训练按下杠杆以获得红外热脉冲。一半的动物接受双侧电解质损伤的外侧下丘脑和一半的假手术。损伤组和对照组动物术后表现相似，并对奖励持续时间和强度的变化做出适当反应。因此，外侧下丘脑病变不损害行为体温调节。尽管正常的行为热量摄入，但在治疗期间，病变大鼠的体温显著下降，这可以归因于病变导致的代谢产热受损。
Rats exposed to the cold (−9°C) were trained to depress a lever to obtain pulses of infrared heat. Half of the animals received bilateral electrolytic lesions of the lateral hypothalamus and half were sham operated. Lesioned and control animals performed similarly postoperatively and responded appropriately to changes in reward duration and intensity. Thus, lateral hypothalamic lesions do not impair behavioral thermoregulation. Despite normal behavioral heat intake, body temperature of the lesioned rats fell significantly during the sessions, which can be attributed to an impairment in metabolic heat production due to the lesions.