Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?
Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?
复制标题
糖尿病酮症酸中毒儿童的液体治疗：儿科急救应用研究网络糖尿病酮症酸中毒研究中的液体疗法（FLUID）试验的结果如何改变我们的观点？
DOI：
10.1111/pedi.12795
复制
发表时间：
2019
影响因子：
3.4
通讯作者：
Kuppermann,Nathan
中科院分区：
文献类型：
--
作者：
Glaser,Nicole;Kuppermann,Nathan
糖尿病酮症酸中毒（DKA）儿童的最佳液体治疗方案长期以来一直存在争议。直到最近，还没有来自随机临床试验的高质量证据来支持最佳指南，建议主要基于理论考虑。因此，DKA儿童的液体治疗方案因机构（和国家）而异。2018年6月，在儿科急诊应用研究网络中进行的DKA试验中的液体治疗研究结果发表。这项大型、析因设计的随机对照试验评估了1387名DKA儿童的神经系统结局，这些儿童接受了四种输液方案之一的治疗，输液速率和钠含量各不相同。在这篇评论中，我们回顾并讨论了这项新研究的结果以及对儿童DKA临床护理的影响。
The optimal fluid treatment protocol for children with diabetic ketoacidosis (DKA) has long been a subject of controversy. Until recently, there was no high‐quality evidence from randomized clinical trials to support an optimal guideline, and recommendations were mainly based on theoretical considerations. As a consequence, fluid treatment protocols for children with DKA vary between institutions (and countries). In June 2018, the results from the Fluid Therapies Under Investigation in DKA Trial conducted in the Pediatric Emergency Care Applied Research Network were published. This large, factorial‐designed randomized controlled trial assessed neurological outcomes of 1387 children with DKA who were treated with one of four fluid protocols that varied in infusion rate and sodium content. In this commentary, we review and discuss the results of this new study and the implications for clinical care of DKA in children.