Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity
Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity
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DOI：
10.1007/s10517-005-0396-x
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发表时间：
2005-07-01
影响因子：
0.7
通讯作者：
Plekhanov, AY
中科院分区：
文献类型：
--
作者：
Mokrushin, AA;Pavlinova, LI;Plekhanov, AY
用浓度为1 μ g/ml的热休克蛋白对培养的大鼠脑嗅皮质切片进行预孵育，可以保护痛风能突触传递的突触前和突触后机制免受谷氨酸兴奋毒性（50 mM）引起的兴奋性突触后功能阻断和突触前过程减少的影响。假设热休克蛋白保护AMPA和NMDA受体介导的过程。
Preincubation of cultured slices of the olfactory cortex of rat brain with heat shock protein in a concentration of 1 mu g/ml protected the pre- and postsynaptic mechanisms of goutamatergic synaptic transmission from glutamate excitotoxicity (50 mM) inducing blockade of excitatory postsynaptic function and reducing presynaptic processes. It was hypothesized that heat shock protein protects AMPA and NMDA receptor-mediated processes.