T1DBase: integration and presentation of complex data for type 1 diabetes research.
T1DBase: integration and presentation of complex data for type 1 diabetes research.
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DOI：
10.1093/nar/gkl933
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Goodman, Nathan
中科院分区：
文献类型：
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作者：
Hulbert, Erin M;Smink, Luc J;Adlem, Ellen C;Allen, James E;Burdick, David B;Burren, Oliver S;Cassen, Victor M;Cavnor, Christopher C;Dolman, Geoffrey E;Flamez, Daisy;Friery, Karen F;Healy, Barry C;Killcoyne, Sarah A;Kutlu, Burak;Schuilenburg, Helen;Walker, Neil M;Mychaleckyj, Josyf;Eizirik, Decio L;Wicker, Linda S;Todd, John A;Goodman, Nathan
T1 DBase（）[Smink等人（2005）Nucleic Acids Res.，33，D544-D549;布尔伦等人（2004）J. Genomics，1，98-109]是支持1型糖尿病（T1 D）研究社区的公共网站和数据库。T1 DBase为医学研究人员所面临的复杂数据世界提供了一个面向T1 D的统一视图，使科学家能够从他们已知的信息导航到新的信息。基因和标记的概述页面总结了这些元素的信息。基因档案总结了一系列基因的信息。GBrowse [Stein等人（2002）Genome Res.，10，1599-1610]在其基因组背景中显示基因和其它特征，而Cytoscape [Shannon等人（2003）Genome Res.，13，2498-2504]显示了在相互作用的蛋白质和基因的背景下的基因。β细胞基因图谱显示β细胞、胰岛和相关细胞类型和细胞系中的基因表达，组织表达查看器显示其他组织中的表达。Microarray Viewer显示来自20多个阵列实验的表达。β细胞基因表达库包含β细胞中表达基因的手动管理基因和途径注释。T1 DMart是一个标记和基因型查询工具。PosterPages是关于特定主题或数据集的“主页”。现在和未来的关键挑战是为T1 D科学家提供强大的信息学能力，使他们能够用来加强他们的研究。
T1DBase () [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res., 10, 1599–1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res., 13, 2498–2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in β cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in β cells. T1DMart is a query tool for markers and genotypes. PosterPages are ‘home pages’ about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research.