Novel applications of ethyl glyoxalate with the Ugi MCR
Novel applications of ethyl glyoxalate with the Ugi MCR
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DOI：
10.1016/s0040-4039(99)00960-0
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发表时间：
1999-07-16
影响因子：
1.8
通讯作者：
Cherrier, MP
中科院分区：
文献类型：
--
作者：
Hulme, C;Cherrier, MP
This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization. (C) 1999 Elsevier Science Ltd. All rights reserved.
