Effect of histamine on intestinal fluid secretion in the dog.
Effect of histamine on intestinal fluid secretion in the dog.
复制标题
组胺对狗肠液分泌的影响。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
J. Silverberg
中科院分区：
文献类型：
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作者：
J. S. Lee;J. Silverberg
动脉内注入组胺可使小肠血流量增加一倍左右，肠组织和肠系膜水肿，并产生大量液体分泌。空肠分泌物的离子组成与血浆相似，而回肠分泌物含有高浓度的HCO 3和相对低浓度的Cl。分泌物含有蛋白质（1.5 +/- .2 g/100 ml，范围0.5-2.4），具有与血浆蛋白相似的电泳图谱。当丽丝胺绿色存在于血液中时，它也以相当高的浓度出现在分泌物中。从这些发现推断，组胺作用下液体分泌的主要机制涉及通过由广泛毛细血管渗漏引起的组织液压力增加而穿过粘膜上皮的过滤过程。
Intra-arterial infusion of histamine into the small intestine caused about a onefold increase of blood flow, edema of the intestinal tissues and mesentery, and produced a copious secretion of fluid. The jejunal secretions had an ionic composition similar to that of plasma, whereas ileal secretions contained high concentrations of HCO3 with relative low concentrations of Cl. The secretions contained protein (1.5 +/- .2 g/100 ml, range 0.5-2.4) with a similar electrophoretic pattern of plasma protein. When lissamine green was present in the blood, it also appeared in the secretion to a considerable concentration. It is inferred from these findings that a major mechanism of fluid secretion by the action of histamine involves a filtration process across the mucosal epithelium by the incrreased tissue fluid pressure due to extensive capillary leak.