Preference Conditioning in Healthy Individuals: Correlates With Hazardous Drinking
Preference Conditioning in Healthy Individuals: Correlates With Hazardous Drinking
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DOI：
10.1111/j.1530-0277.2010.01175.x
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发表时间：
2010-06-01
影响因子：
3.2
通讯作者：
Olmstead, Mary C.
中科院分区：
文献类型：
--
作者：
Balodis, Iris M.;Lockwood, Kathleen P.;Olmstead, Mary C.
背景：条件奖赏是成瘾动物模型中药物诱导的脑变化的经典测量方法。这个过程可以在人类中使用条件模式偏好（CPP）任务进行检查，在该任务中，参与者将非语言线索与奖励联系起来，但对这种条件反射的意识较低。在此之前，我们报告说，酒精中毒不影响CPP收购在人类，但我们的数据表明，以前的药物使用可能会影响条件scores.Methods：为了测试这种可能性，目前的研究探讨了自我报告的酒精使用和偏好条件之间的关系在CPP任务。在条件反射过程中，通过要求参与者计算出现在计算机屏幕上每个位置的提示来评估工作记忆。参与者（69名女性和23名男性本科生）完成了酒精使用障碍识别测试（AUDIT）和罗格斯大学酒精问题指数（RAPI）作为危险drinking.Results的措施：自我报告的危险饮酒与偏好条件显着相关，在这些尺度上得分较高的个人表现出增加的偏好奖励配对线索。与此相反，危险的饮酒并没有影响工作记忆错误的CPP task.Conclusions：这些研究结果支持的证据表明，反复使用药物的敏感性神经通路介导的条件奖励和指向一个神经认知的处置链接物质滥用和反应奖励配对刺激。危险饮酒和条件性奖励之间的关系独立于认知功能的变化，如工作记忆。
Background:Conditioned reward is a classic measure of drug-induced brain changes in animal models of addiction. The process can be examined in humans using the Conditioned Pattern Preference (CPP) task, in which participants associate nonverbal cues with reward but demonstrate low awareness of this conditioning. Previously, we reported that alcohol intoxication does not affect CPP acquisition in humans, but our data indicated that prior drug use may impact conditioning scores.Methods:To test this possibility, the current study examined the relationship between self-reported alcohol use and preference conditioning in the CPP task. Working memory was assessed during conditioning by asking participants to count the cues that appeared at each location on a computer screen. Participants (69 female and 23 male undergraduate students) completed the Alcohol Use Disorders Identification Test (AUDIT) and the Rutgers Alcohol Problem Index (RAPI) as measures of hazardous drinking.Results:Self-reported hazardous drinking was significantly correlated with preference conditioning in that individuals who scored higher on these scales exhibited an increased preference for the reward-paired cues. In contrast, hazardous drinking did not affect working memory errors on the CPP task.Conclusions:These findings support evidence that repeated drug use sensitizes neural pathways mediating conditioned reward and point to a neurocognitive disposition linking substance misuse and responses to reward-paired stimuli. The relationship between hazardous drinking and conditioned reward is independent of changes in cognitive function, such as working memory.