Suppression of Recurrent Genital Herpes Simplex Virus Infection with Recombinant α2 Interferon
Suppression of Recurrent Genital Herpes Simplex Virus Infection with Recombinant α2 Interferon
复制标题
重组α2干扰素抑制复发性生殖器单纯疱疹病毒感染
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Y. Bryson
中科院分区：
文献类型：
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作者：
T. Kuhls;J. Sacher;E. Pineda;D. Santomauro;E. Wiesmeier;W. Growdon;Y. Bryson
这项双盲、安慰剂对照研究评价了皮下注射重组α 2干扰素（IFN-α 2）抑制频繁复发的生殖器单纯疱疹病毒（HSV）感染的疗效和安全性。76名在前一年中有8次或更多复发的健康受试者接受了1 × 10（6）IU的IFN-α 2，3 × 10（6）IU的IFN-α 2或安慰剂，每周3次，持续12周。接受较高剂量IFN-α 2的患者在研究期间爆发较少（2 vs. 3），病毒脱落时间较短（2 vs. 4天），瘙痒较少（1 vs. 3天），愈合时间更快（6 vs. 8天）。较低剂量的IFN-α 2无效。91%的受试者在首次注射3 × 10（6）IU IFN-α 2后出现明显的副作用（发热、不适、肌痛、疲劳和关节痛），但随后的注射仅产生轻微的间歇性副作用，耐受性良好。在用IFN-α 2治疗的受试者中观察到轻度白细胞减少症。IFN-α 2治疗可中度抑制复发性生殖器HSV感染，并可缩短复发性HSV感染的持续时间。
This double-blind, placebo-controlled study evaluated the efficacy and safety of sc administered recombinant alpha 2 interferon (IFN-alpha 2) in the suppression of frequently recurrent genital herpes simplex virus (HSV) infection. Seventy-six otherwise healthy subjects who had eight or more recurrences during the preceding year received 1 X 10(6) IU of IFN-alpha 2, 3 X 10(6) IU of IFN-alpha 2, or placebo three times per week for 12 weeks. Recipients of the higher dose of IFN-alpha 2, had fewer outbreaks during the study (2 vs. 3), a shorter period of viral shedding (2 vs. 4 days), less itching (1 vs. 3 days), and a faster healing time (6 vs. 8 days). The lower dose of IFN-alpha 2 was not effective. Significant side effects (fever, malaise, myalgia, fatigue, and arthralgia) occurred after the first injection of 3 X 10(6) IU of IFN-alpha 2 in 91% of the subjects, but subsequent injections produced only mild and intermittent side effects that were well tolerated. Mild leukopenia was noted in subjects treated with IFN-alpha 2. Treatment with IFN-alpha 2 resulted in moderate suppression and decreased duration of recurrent genital HSV infection in patients with frequent recurrences.