Risk factors for death and changing patterns in leptospirosis acute renal failure
Risk factors for death and changing patterns in leptospirosis acute renal failure
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DOI：
10.4269/ajtmh.1999.61.630
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发表时间：
1999-10-01
影响因子：
3.3
通讯作者：
Abdulkader, RCRM
中科院分区：
文献类型：
--
作者：
Daher, E;Zanetta, DMT;Abdulkader, RCRM
钩端螺旋体病（韦氏病）死亡的危险因素和临床模式的变化尚未得到很好的研究。我们回顾性研究了110例韦伊病住院在巴西之间的1985年和1996年。单因素统计分析显示，死亡者年龄大于存活者，少尿、心律失常、呼吸困难和肺部罗音的发生率更高。Logistic回归分析显示，与死亡相关的唯一独立因素是少尿（比值比[OR] = 8.98）。1994年以后，关节痛（OR = 4.71）、脱水（OR = 6.26）、呼吸困难（OR = 17.7）和肺部罗音（OR = 9.91）的发生率增加。这些数据表明，在韦尔氏病的临床模式已经改变，少尿的存在是死亡的危险因素。
The risk factors for death and changes in clinical patterns in leptospirosis (Weil's disease) have not been well studied. We retrospectively studied 110 patients with Weil's disease hospitalized in Brazil between 1985 and 1996. Univariate statistical analysis showed that nonsurvivors were older than survivors, and had higher frequency of oliguria, cardiac arrhythmia, dyspnea, and pulmonary rales. Logistic regression showed that the only independent factor associated with death was oliguria (odds ratio [OR] = 8.98). The presence of arthralgia (OR = 4.71), dehydration (OR = 6.26), dyspnea (OR = 17.7),and pulmonary rales (OR = 9.91) increased after 1994. These data suggest that in Well's disease the clinical patterns have changed and the presence of oliguria is a risk factor for death.