Effects of Jitai tablet, a traditional Chinese medicine, on plasma adrenocorticotropic hormone and cortisol levels in heroin addicts during abstinence.
Effects of Jitai tablet, a traditional Chinese medicine, on plasma adrenocorticotropic hormone and cortisol levels in heroin addicts during abstinence.
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DOI：
10.1089/acm.2012.0804
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发表时间：
2014-07
影响因子：
2.6
通讯作者：
H. Fan;Li Sun;Xiao-xiao Li;Shao-bo Zhou;Jun-cheng Liang;B. Yan;Y. Li;Yan-ping Deng
中科院分区：
文献类型：
--
作者：
H. Fan;Li Sun;Xiao-xiao Li;Shao-bo Zhou;Jun-cheng Liang;B. Yan;Y. Li;Yan-ping Deng
目的探讨吉太片戒断期间海洛因依赖者促肾上腺皮质激素（ACTH）和皮质醇的变化。设计：双盲、随机、安慰剂对照临床试验。单位/地点中国上海警方戒毒局。参与者99名志愿者，包括69名海洛因成瘾者和30名健康志愿者。干预措施69名海洛因成瘾者随机分为两组：吉太片组，34名海洛因成瘾者在戒断期间服用吉太片；安慰剂组，35名海洛因成瘾者服用安慰剂。控制组由30名性别和年龄相匹配的健康志愿者组成。所有组在基线时以及吉太片组和安慰剂组在戒断后第3天、第7天和第14天测量血浆ACTH和皮质醇。结果海洛因依赖者ACTH水平（p< 0.01）和皮质醇水平（p< 0.001）均显著高于健康志愿者。吉太片组血浆皮质醇恢复正常的速度比安慰剂组快（p< 0.05），但ACTH恢复正常的速度比安慰剂组快（p< 0.05）。ACTH和皮质醇基线值与戒断症状评分和海洛因日剂量呈正相关（p< 0.01）。结论吉太片可通过改变下丘脑-垂体-肾上腺轴对海洛因依赖者产生反应。
OBJECTIVES To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence. DESIGN Double-blind, randomized, placebo-controlled clinical trial. SETTINGS/LOCATION Drug Rehabilitation Bureau of Shanghai Police, China. PARTICIPANTS 99 volunteers, including 69 heroin addicts and 30 healthy volunteers. INTERVENTIONS 69 heroin addicts randomly divided into two groups: the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo. A control group consisted of 30 sex- and age-matched healthy volunteers. OUTCOME MEASURES ACTH and cortisol in plasma were measured in all groups at baseline and in the Jitai tablet and placebo groups on the third, seventh, and 14th days of abstinence. RESULTS Levels of both ACTH (p<.01) and cortisol (p<.001) were significantly higher in heroin addicts at baseline than in the healthy volunteers. Jitai tablet treatment restored plasma cortisol levels to normal more rapidly than did placebo treatment (p<.05), but not ACTH levels. A positive correlation between ACTH and cortisol values at baseline (p<.01) was also found with withdrawal symptom scores and daily dosages of heroin. CONCLUSIONS Heroin addicts could respond to Jitai tablets through changes in the hypothalamus-pituitary-adrenal axis.