LATERAL ASYMMETRY OF NEUROTRANSMITTERS IN HUMAN-BRAIN
LATERAL ASYMMETRY OF NEUROTRANSMITTERS IN HUMAN-BRAIN
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DOI：
10.1016/0006-8993(82)90472-3
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
HOUGH, LB
中科院分区：
文献类型：
--
作者：
GLICK, SD;ROSS, DA;HOUGH, LB
最近发表的数据表明很少或没有证据表明死后人脑中存在神经递质不对称，我们用相关分析和卡方检验对这些数据进行了分析。尽管没有惯用手的数据，也不可能确定不对称的功能意义，但分析表明，在几个大脑结构和发射系统中确实存在不对称。结构与递质之间及其内部的左右不对称性呈非随机分布的显著相关，谷氨酸脱羧酶(GAD)和GABA的左右不对称性在所有9个结构中均呈正相关；同一结构内不同神经递质的左右不对称性之间呈正相关，而不同结构之间的相关呈负相关：两种趋势均显著。经卡方检验，苍白球胆碱乙酰转移酶(ChAT)和多巴胺(DA)均显著左偏，苍白球ChAT和DA的左右不对称与尾状核和壳核的左右不对称呈正相关。ChAT和GAD的左右不对称在所有皮质区域呈正相关，在所有黑质纹状体结构呈负相关。在尾状核、壳核和苍白球，多巴胺水平较低的大脑有向左倾斜的显著趋势，反之亦然。苍白球ChAT的绝对不对称性与年龄呈高度负相关；(8)不同结构中相同或不同神经递质的绝对不对称性通常呈正相关，表明每个特定的脑可能具有不同程度的不对称性。人类的数据与之前在老鼠身上报告的数据有几个相似之处，表明在老鼠身上进行的研究可能会揭示与人类相关的大脑不对称的机制和功能。
Data recently published as indicating little or no evidence of neurotransmitter asymmetries in post-mortem human brain were analyzed by correlational and Chi-square procedures. Although handedness data were not available and it was not possible to determine the functional significance of asymmetries, analysis shows that asymmetries in several brain structures and transmitter systems do exist. Correlations of left-right asymmetries between and within structures and transmitters yielded a non-random distribution of significant correlations, left-right asymmetries in glutamic acid decarboxylase (GAD) and GABA were positively correlated in all 9 structures examined; correlations between left-right asymmetries of different neurotransmitters within the same structure tended to be positive whereas correlations between different structures tended to be negative: both trends were significant. Choline acetyltransferase (ChAT) and dopamine (DA) were both significantly left-biased, by Chi-square tests, in globus pallidus; left-right asymmetries in ChAT and DA were positively correlated in globus pallidus, as well as in caudate nucleus and putamen. Left-right asymmetries in ChAT and GAD were positively correlated in all cortical areas and negatively correlated in all nigrostriatal structures. In caudate, putamen and globus pallidus, there was a significant trend for brains with lower dopamine levels to be left-biased and vice-versa. There was a highly significant inverse correlation of age with the absolute asymmetry in globus pallidus ChAT; (8) correlations of absolute asymmetries between the same or different neurotransmitters in different structures were usually positive, indicating that a greater or lesser degree of asymmetry probably characterizes each particular brain. There were several similarities between the human data and those previously reported in rats, demonstrating that studies in the rat may reveal mechanisms and functions of brain asymmetry that are relevant to man.