A Bronsted acid catalyst for the enantioselective protonation reaction
A Bronsted acid catalyst for the enantioselective protonation reaction
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DOI：
10.1021/ja8041542
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发表时间：
2008-07-23
影响因子：
15
通讯作者：
Yamamoto, Hisashi
中科院分区：
文献类型：
--
作者：
Cheon, Cheol Hong;Yamamoto, Hisashi
合成了一种高活性、高稳定性的手性Bronsted酸催化剂--手性N-三氟甲磺酰基硫代磷酰胺，首次实现了无金属催化的烯醇醚硅酯的不对称质子化反应.催化剂的负载量可以降低到0.05mol%，对映选择性没有任何有害影响。
A highly reactive and robust chiral Bronsted acid catalyst, chiral N-triflyl thiophosphoramide, was developed, The first metal-free Bronsted acid catalyzed enantioselective protonation reaction of silyl enol ethers was demonstrated using this chiral Bronsted acid catalyst. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity.