Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study
Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study
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DOI：
10.1080/1028415x.2021.1885241
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发表时间：
2021-02-11
影响因子：
3.6
通讯作者：
Arakawa, Masashi
中科院分区：
文献类型：
--
作者：
Miyake, Yoshihiro;Tanaka, Keiko;Arakawa, Masashi
母亲孕期金属摄入量低可能影响儿童发育。目前出生前的队列研究调查了母亲摄入锌，镁，铁，铜，锰在怀孕期间和行为问题，在日本儿童5 years.MethodsSubjects是1199母子对之间的关系。使用饮食史问卷评估前一个月的饮食摄入量。情绪，行为，多动症，同伴问题和低亲社会行为进行了评估，使用优势和困难问卷。母亲年龄、基线妊娠、居住地区、孩子数量、母亲和父亲的教育程度、家庭收入、母亲怀孕期间的抑郁症状、母亲怀孕期间的饮酒量、母亲怀孕期间吸烟、孩子的出生体重、孩子的性别、母乳喂养持续时间、出生后第一年家庭吸烟情况，和一些饮食混杂因素，与研究中的结果在这一人群进行了调整。结果相比，母亲镁摄入量在怀孕期间的第一个四分位数，镁摄入量在第二，第三，第四个四分位数与儿童期多动问题呈独立负相关，但与情绪、行为或同伴问题或低亲社会行为无关：极端四分位数之间的校正比值比为0.48（95%置信区间：0.23-0.99，趋势P = 0.04）。母亲摄入锌，铁，铜，或锰在怀孕期间和儿童的情绪，行为，多动症，或同龄人的问题或低亲社会behaviors.ConclusionsThe本研究表明，母亲在怀孕期间镁的摄入量较高，与多动症的问题在日本儿童呈负相关。
ObjectivesLower maternal metal intake during pregnancy might affect childhood development. The current prebirth cohort study investigated the relationship between maternal intake of zinc, magnesium, iron, copper, and manganese during pregnancy and behavioral problems in Japanese children aged five years.MethodsSubjects were 1199 mother-child pairs. Dietary intake during the preceding month was assessed using a diet history questionnaire. Emotional, conduct, hyperactivity, and peer problems and low prosocial behavior were assessed using the Strengths and Difficulties Questionnaire. Maternal age, gestation at baseline, region of residence, number of children, maternal and paternal education, household income, maternal depressive symptoms during pregnancy, maternal alcohol intake during pregnancy, maternal smoking during pregnancy, child's birth weight, child's sex, breastfeeding duration, smoking in the household during the first year of life, and some dietary confounders that were associated with outcomes under study in this population were adjusted for.ResultsCompared with maternal magnesium intake during pregnancy in the first quartile, magnesium intake in the second, third, and fourth quartiles was independently inversely related to childhood hyperactivity problems, but not to emotional, conduct, or peer problems or low prosocial behavior: the adjusted odds ratio between extreme quartiles was 0.48 (95% confidence interval: 0.23-0.99, P for trend = 0.04). No evident associations were observed between maternal intake of zinc, iron, copper, or manganese during pregnancy and childhood emotional, conduct, hyperactivity, or peer problems or low prosocial behavior.ConclusionsThe present study suggests that higher maternal magnesium intake during pregnancy is inversely associated with hyperactivity problems in Japanese children.