Orexin A Elicits Arousal Electroencephalography Without Sympathetic Cardiovascular Activation in Isoflurane-Anesthetized Rats
Orexin A Elicits Arousal Electroencephalography Without Sympathetic Cardiovascular Activation in Isoflurane-Anesthetized Rats
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DOI：
10.1213/01.ane.0000089964.85834.ef
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发表时间：
2003-12
影响因子：
5.7
通讯作者：
Y. Yasuda;A. Takeda;S. Fukuda;Hisato Suzuki;Masayuki Ishimoto;Yoshiteru Mori;H. Eguchi;R. Saitoh;H. Fujihara;K. Honda;T. Higuchi
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文献类型：
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作者：
Y. Yasuda;A. Takeda;S. Fukuda;Hisato Suzuki;Masayuki Ishimoto;Yoshiteru Mori;H. Eguchi;R. Saitoh;H. Fujihara;K. Honda;T. Higuchi
在异氟醚麻醉下，研究了脑室注射新型神经肽增食欲素A对大鼠脑电和自主神经活动的影响。在1.0最低肺泡麻醉浓度(MAC)异氟醚时，给予食欲素A可使脑电爆发抑制模式变为唤醒模式，并降低1.5MAC异氟醚时的爆发抑制率。然而，食欲素A在任何一种异氟醚浓度下都不影响心率或平均动脉压。这些结果表明，在异氟醚麻醉下，食欲素A在没有交感心血管激活的情况下引起大鼠的脑电模式的麻醉唤醒。
We studied the effects of intracerebroventricular injection of the novel neuropeptide orexin A on electroencephalogram (EEG) and autonomic nervous system activity in rats under isoflurane anesthesia. The administration of orexin A changed burst suppression patterns to arousal patterns on the EEG at 1.0 minimum alveolar anesthetic concentration (MAC) isoflurane and decreased the burst suppression ratio at 1.5 MAC isoflurane. However, orexin A did not influence the heart rate or mean arterial blood pressure at either isoflurane concentration. These findings demonstrated that orexin A elicited anesthetic arousal under isoflurane anesthesia in terms of EEG pattern without sympathetic cardiovascular activation in the rat.