Prognosis of Hippocampal Function after Sub-lethal Irradiation Brain Injury in Patients with Nasopharyngeal Carcinoma.
Prognosis of Hippocampal Function after Sub-lethal Irradiation Brain Injury in Patients with Nasopharyngeal Carcinoma.
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DOI：
10.1038/s41598-017-13972-2
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发表时间：
2017-10-31
影响因子：
4.6
通讯作者：
Hisatsune T
中科院分区：
文献类型：
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作者：
Chen SC;Abe Y;Fang PT;Hsieh YJ;Yang YI;Lu TY;Oda S;Mitani H;Lian SL;Tyan YC;Huang CJ;Hisatsune T
这项工作强调的价值，评估海马功能，及时作出基于MRI的预后后，小剂量海马照射鼻咽癌（NPC）放疗。采用病例对照设计和功能评估的准实验（例如，用fMRI进行神经成像分析）以评估放射治疗后海马的功能。我们用6 MV螺旋线放射治疗鼻咽癌，剂量为70戈伊，收集了20例鼻咽癌患者和24例年龄匹配的健康受试者的数据。不可避免的是，雷坎皮也接受了平均6.89戈伊（范围，2.0-14戈伊）的剂量。应用基于种子的海马功能连接性来估计照射前、照射后1个月和4个月的认知改变。之后，用控制协方差的时间相关测量方差分析（ANOVA）确定了跨时段和跨时段的统计推断。随着时间的推移，有纵向变化的功能连接的大脑皮层，包括右中额叶，左上级颞叶，左中央后回。研究结果表明存在的功能可塑性，展示了如何轻微照射影响功能的表现在早期延迟阶段的辐射诱导的脑损伤。
This work emphasizes the value of assessing hippocampal function by making a timely MRI-based prognosis following a minor dose of hippocampal irradiation after nasopharyngeal carcinomas (NPC) radiotherapy. A quasi-experiment with case-control design and functional assessments (e.g., neuroimaging analysis with fMRI) was conducted to assess hippocampal function after radiotherapy. We delivered 70 Gy of irradiation to nasopharyngeal carcinomas by 6MV helical radiotherapy and collected data from twenty NPC patients and 24 healthy age-matched subjects. Inevitably, hippocampi also received an average dose of 6.89 Gy (range, 2.0–14 Gy). Seed-based functional connectivity of the hippocampus was applied to estimate the cognitive alteration by time before, one month, and four months after irradiation. Afterward, longitudinal-and-cross-sessional statistical inference was determined with time-dependent measurement analysis of variance (ANOVA) with controlled covariance. Over time, there were longitudinal changes in the functional connectivity of hippocampal-related cortices, including the right middle frontal lobe, left superior temporal lobe, and left postcentral gyrus. The findings indicate the presence of functional plasticity, demonstrating how minor irradiation affects functional performance during the early delayed phase of irradiation-induced brain injury.