Feasibility of diffuse optical imaging with long-lived luminescent probes
Feasibility of diffuse optical imaging with long-lived luminescent probes
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DOI：
10.1364/ol.31.001082
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发表时间：
2006-04-15
期刊：
影响因子：
3.6
通讯作者：
Vinogradov, SA
中科院分区：
文献类型：
--
作者：
Apreleva, SV;Wilson, DE;Vinogradov, SA
最近出现了具有高量子产率的长寿命近红外荧光粉，使得对组织中的氧分布进行三维成像成为可能。通过数值模拟，我们证明，通过使用具有适当氧猝灭常数的磷光探针，可以采用简单的时间选通测量，以足够的空间分辨率对散射介质中的缺氧体模进行成像。开发的方法将指导活体组织中磷光寿命和氧压的实验成像。 (c) 2006 年美国光学学会。
Long-lived near-infrared phosphors with high quantum yields have recently become available, making it possible to image oxygen distributions in tissue in three dimensions. By numerical simulations we demonstrate that, by using phosphorescent probes with appropriate oxygen quenching constants, one can image hypoxic phantoms in scattering media with adequate spatial resolution, employing simple time-gated measurements. The approach developed will guide experimental imaging of phosphorescence lifetime and oxygen pressure in living tissue. (c) 2006 Optical Society of America.