MEPHENESIN, METHOCARBAMOL, CHLORDIAZEPOXIDE AND DIAZEPAM . ACTIONS ON SPINAL REFLEXES AND VENTRAL ROOT POTENTIALS
MEPHENESIN, METHOCARBAMOL, CHLORDIAZEPOXIDE AND DIAZEPAM . ACTIONS ON SPINAL REFLEXES AND VENTRAL ROOT POTENTIALS
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DOI：
10.1111/j.1476-5381.1970.tb10343.x
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发表时间：
1970-01-01
影响因子：
7.3
通讯作者：
RAPER, C
中科院分区：
文献类型：
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作者：
CRANKSHAW, DP;RAPER, C
1消除多突触反射收缩的剂量水平的美芬甘油醚、美索巴莫、利氮卓和地西泮对氯醛糖麻醉的猫的单突触膝跳反射没有影响。2刺激相应的背根后记录背根电位（L7或S1），通过平面测量法测量单突触和多突触成分的面积。3消除多突触反射收缩的药物的剂量水平使腹根电位的多突触成分的面积减少约50%。美芬甘油醚和美索巴莫减少了单突触组件的面积到类似的程度。在这方面，氯氮卓的效力较低，而地西泮在该剂量水平下无作用。4随着四种药物中每种药物剂量的增加，计算腹根电位的单突触和多突触成分降低的线性回归线。与美索巴莫和美芬醚的线是平行和重合的。使用利血平和地西泮时，它们是平行的，但不一致。需要大剂量的地西泮来减少单突触成分的面积，这种药物是四种测试药物中唯一一种对两种成分具有差异作用的药物，具有统计学意义。5根据药物对α-运动神经元的抑制作用，药物在与运动功能有关的高级中心的作用，以及缺乏脊髓中间神经元代表中枢作用骨骼肌松弛剂的特定作用部位的证据。
1Dose levels of mephenesin, methocarbamol, chlordiazepoxide and diazepam which abolished polysynaptic reflex contractions had no effect on monosynaptic knee‐jerk reflexes in chloralose anaesthetized cats.2Ventral root potentials were recorded following stimulation of the corresponding dorsal root (L7 or S1), and the areas of the mono‐ and polysynaptic components were measured by planimetry.3Dose levels of the drugs which abolished polysynaptic reflex contractions reduced the areas of the polysynaptic component of the ventral root potentials by about 50%. Mephenesin and methocarbamol reduced the area of the monosynaptic component to a similar extent. Chlordiazepoxide was less potent in this respect while diazepam was without effect at this dose level.4Linear regression lines were calculated for the reduction in the mono‐ and polysynaptic components of ventral root potentials with increasing doses of each of the four drugs. With methocarbamol and mephenesin the lines were parallel and coincident. With chlordiazepoxide and diazepam they were parallel but not coincident. Large doses of diazepam were required to reduce the area of the monosynaptic component, this drug being the only one of the four tested to have a differential action on the two components which was statistically significant.5The results are discussed in terms of depressant actions of the drugs on α‐motorneurones, effects of the drugs at higher centres concerned with motor function, and the lack of evidence that spinal interneurones represent a specific site of action for centrally acting skeletal muscle relaxants.