Nitric oxide signaling triggered by the rheumatoid arthritis-shared epitope - A new paradigm for MHC-Disease association?
Nitric oxide signaling triggered by the rheumatoid arthritis-shared epitope - A new paradigm for MHC-Disease association?
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DOI：
10.1196/annals.1423.009
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Ling, Song
中科院分区：
文献类型：
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作者：
Holoshitz, Joseph;Ling, Song
Many immune-mediated diseases are associated with particular MHC class I or class II alleles. In rheumatoid arthritis (RA-shared), the vast majority of patients possess HLA-DRB1 alleles encoding a shared epitope, which is a five-amino acid sequence motif in positions 70-74 of the HLA-DR beta chain. The mechanistic basis for this association is unknown. Here we discuss recent evidence suggesting that the shared epitope may act as an allele-specific ligand that triggers increased nitric oxide (NO) production in opposite cells with resultant immune dysregulation. We propose that by doing that, the RA-shared shared epitope may form an unintended bridge between the innate and adaptive immune systems, thereby allowing aberrant signaling events that could trigger disease.
