Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study.
Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study.
复制标题
听力图上明显不同的突发感音神经性听力损失患者血小板相关参数的差异
DOI：
10.1097/md.0000000000007877
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发表时间：
2017-09
期刊：
影响因子：
1.6
通讯作者：
Yin S
中科院分区：
文献类型：
--
作者：
Sun Y;Guo Y;Wang H;Chen Z;Wu Y;Shi H;Feng Y;Yin S
摘要：我们探讨了不同听力图数据和常规血数据中血管标志物水平不同的突发性感音神经性听力损失（SSNHL）患者之间可能的关系。我们纳入了 37 名低频 SSNHL (LF-SSNHL) 患者、28 名高频 SSNHL (HF-SSNHL) 患者、32 名全频 SSNHL (AF-SSNHL) 患者、32 名全耳聋 SSNHL (TD-SSNHL) 患者以及 31 名年龄和性别匹配的健康对照者。采集外周静脉血样本，并测量常规血液参数，包括血小板和淋巴细胞计数、平均血小板体积（MPV）和血小板与淋巴细胞比值（PLR）。治疗1个月后根据听力水平将各组分为恢复亚组和未恢复亚组，比较2个亚组间血小板和淋巴细胞计数、MPV、PLR的差异。所有SSNHL患者的血小板计数与对照组相比均无显着性差异（均P > .05）。所有SSNHL患者AF-SSNHL和TD-SSNHL的MPV、PLR均显着高于对照组（均P < .05），而所有听力图不同的SSNHL患者淋巴细胞计数均显着低于对照组（均P < .05）。然而，听力图不同的SSNHL患者的血小板计数、淋巴细胞计数、MPV和PLR差异不显着（均P > .05）。 HF-SSNHL患者中，未恢复亚组淋巴细胞计数显着低于恢复亚组，而未恢复亚组MPV和PLR显着高于恢复亚组（均P < .05）。 AF-SSNHL患者中，未恢复组MPV显着高于恢复亚组（P < .05）。淋巴细胞计数、MPV 和 PLR 可能与 SSSNHL 有关，但它们不能用于在听力学上区分 SSNHL。较低的淋巴细胞、较高的 MPV 和 PLR 可能预示着 HF-SSNHL 患者的预后；较高的 MPV 可能与 AF-SSNHL 患者的不良治疗结果有关。
Abstract We explored possible relationships between sudden sensorineural hearing loss (SSNHL) in patients differing in terms of audiographic data and the levels of vascular markers in routine blood data. We included 37 patients with low-frequency SSNHL (LF-SSNHL), 28 with high-frequency SSNHL (HF-SSNHL), 32 with all-frequency SSNHL (AF-SSNHL), 32 with total-deafness SSNHL (TD-SSNHL), and 31 age- and sex-matched healthy controls. Peripheral venous blood samples were collected, and routine blood parameters including platelet and lymphocyte count, mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) were measured. Each group was divided into recovery subgroup and unrecovery subgroup in accordance with hearing level after 1 month therapy, then compared the difference of platelet and lymphocyte count, MPV, and PLR between the 2 subgroups. No significant difference was observed between platelet count of all SSNHL patients and control group (all P > .05). MPV of AF-SSNHL and TD-SSNHL, PLR of all SSNHL patients were significantly higher than those of control group (all P < .05), while lymphocyte count of all audiographically distinct SSNHL patients was significantly lower than that of control group (all P < .05). However, the difference of platelet count, lymphocyte count, MPV, and PLR among audiographically distinct SSNHL patients was not significant (all P > .05). In HF-SSNHL patients, lymphocyte count of unrecovery subgroup was significantly lower, while MPV and PLR of the unrecovery subgroup were significantly higher than those of recovery subgroup (all P < .05). In AF-SSNHL patients, MPV of the unrecovery group was significantly higher than that of recovery subgroup (P < .05). Lymphocyte count, MPV, and PLR may be relative to SSSNHL, but they could not be used to distinct SSNHL audiographically. Lower lymphocyte, higher MPV, and PLR may be indicative for the prognosis of HF-SSNHL patients; higher MPV may be related to bad treatment outcome of AF-SSNHL patients.