Synthesis of 11β-perfluorohexylestradiol
Synthesis of 11β-perfluorohexylestradiol
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DOI：
10.1021/jo051424k
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发表时间：
2005-10-28
影响因子：
3.6
通讯作者：
Popkin, ME
中科院分区：
文献类型：
--
作者：
Agouridas, V;Blazejewski, JC;Popkin, ME
We report the synthesis of 11 beta-perfluorohexylestradiol le using a perfluoroorganometallic reagent for the introduction of the fluorous part. This compound is useful for biological studies and for imaging the ER alpha estradiol receptor distribution in the whole cell by secondary ion mass spectrometry (SIMS). The key step of this synthesis involves the radical reduction of an 11 beta-oxalate derivative. The stereochemical outcome of this reaction was studied for a range of C11 substituents, and we attempted to rationalize the apparent abnormal behavior of the phenyl group.
