Early adversity and adult health outcomes.
Early adversity and adult health outcomes.
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早期逆境和成人健康结果。
DOI：
10.1017/s0954579411000411
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发表时间：
2011
影响因子：
3.3
通讯作者：
Seeman,TeresaE
中科院分区：
文献类型：
--
作者：
Taylor,ShelleyE;Way,BaldwinM;Seeman,TeresaE
童年的逆境不仅会影响儿童的心理和身体健康，而且会影响人的一生。我们研究的一个主要任务是定义童年经历产生这些令人惊讶的健康结果的途径，通常是几十年后。恒定负荷的概念，指的是跨主要生物调节系统的失调，随着时间的推移，这些系统具有累积的相互作用的不利影响，为理解这些关系和定义特定的途径提供了一种机制。为了绘制这些路径，我们研究了儿童早期的社会经济状况、家庭环境和遗传倾向，作为社会情绪功能/心理痛苦的先行因素；以及对威胁的神经反应，这些威胁对主要的压力调节系统产生下游影响，最终导致对心理和身体健康结果的风险。这种调查童年经历对成人健康结果的影响的综合方法表明了多层次综合方法对更广泛地理解发展精神病理学的重要性。
Adversity in childhood has effects on mental and physical health, not only in childhood but across the lifespan. A chief task of our research has been to define the pathways by which childhood experience has these surprising health outcomes, often decades later. The concept of allostatic load, which refers to dysregulations across major biological regulatory systems that have cumulative interacting adverse effects over time, provides a mechanism for understanding these relations and defining specific pathways. To chart these pathways, we examine early childhood socioeconomic status, family environment, and genetic predispositions as antecedents to socioemotional functioning/psychological distress; and neural responses to threat that have downstream effects on major stress regulatory systems, ultimately culminating in risks to mental and physical health outcomes. This integrative approach to investigating the impact of childhood experience on adult health outcomes illustrates the significance of multilevel integrative approaches to understanding developmental psychopathology more generally.