The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer
The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer
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DOI：
10.1002/pon.3814
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发表时间：
2015-11-01
期刊：
影响因子：
3.6
通讯作者：
Cox, Karen
中科院分区：
文献类型：
--
作者：
Bancroft, Elizabeth K.;Castro, Elena;Cox, Karen
背景识别前列腺癌（PrCa）遗传高危男性的能力将使筛查能够针对那些最需要的人。本研究探讨了心理影响（一般和PrCa具体的担心和风险的看法）对男性的家族史PrCa，前列腺筛查和遗传风险分析，在一项研究study.MethodsA前瞻性探索的方法，采用了顺序混合方法设计。在两个时间点完成问卷，以衡量接受筛查和遗传风险分析的影响。在所有的研究程序完成后，使用框架approach.Results95名男子完成了两份问卷，26人接受了采访，在一个小组完成了深入的采访。在整个小组中没有发现可测量的心理困扰。访谈结果分为两类：感觉处于风险中和生活在风险中。处于PrCa风险中的感觉是男性生活的一部分，由多年来收集的假设和信息形成。男性使用这些信息向同龄人传达PrCa风险。男性高估了他们患PrCa的风险，并有一种先天的假设，即他们会发展PrCa。采访显示，男性在等待筛查结果时经历了严重的焦虑。结论个性化的遗传风险评估并不能阻止男性高估自己的PrCa风险。筛查焦虑是常见的，接收结果的时间应保持在最低限度。男性PrCa风险沟通的方法应该是未来研究的主题。版权所有（c）2015约翰威利父子有限公司
BackgroundThe ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic-risk profiling, within a research study.MethodsA prospective exploratory approach was adopted, incorporating a sequential mixed-method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic-risk profiling. In-depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach.ResultsNinety-five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: feeling at risk' and living with risk'. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results.ConclusionsPersonalised genetic-risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research. Copyright (c) 2015 John Wiley & Sons, Ltd.