Indicators for blood glucose control in diabetics with end - stage chronic renal disease : GHb vs. glycated albumin (GA)
Indicators for blood glucose control in diabetics with end - stage chronic renal disease : GHb vs. glycated albumin (GA)
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DOI：
10.2152/jmi.53.223
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发表时间：
2006-08-01
影响因子：
0.7
通讯作者：
Kawashima, Syu
中科院分区：
文献类型：
--
作者：
Chujo, Keiko;Shima, Kenji;Kawashima, Syu
患有终末期肾病（ESRD）的糖尿病患者表现出异常的红细胞寿命，因此，HbAlc不一定是血糖控制的良好指标。本研究以49例透析前终末期肾病患者（透析前组）、37例透析中终末期肾病患者（透析组）和40例无肾病患者（非透析组）为研究对象，探讨糖化白蛋白（GA）是否可以替代HbAlc。通过每天7次测量血糖水平来计算曲线组平均血糖。然后研究谱集平均血糖与HbAlc和GA水平的关系，通过将每个ESRD患者的谱集平均血糖应用于非透析患者的HbAlc的回归公式来计算校正的HbAlc水平。透析前患者的实际和校正HbAlc水平分别为5.4 +/-1.1和7.9 +/-1.1%，而透析患者的实际和校正HbAlc水平分别为5.6 +/-1.0和7.5 +/-0.9%（p
Diabetics with end-stage renal disease (ESRD) exhibit abnormal life span of erythrocytes, and thus, HbAlc is not necessarily a good indicator for blood glucose control. The present study was conducted to reaffirm this point and determine whether glycated albumin (GA) can be used instead of HbAlc.The following three groups of patients with diabetes served as subjects : 49 predialysis patients with ESRD (predialysis group), 37 patients with ESRD on dialysis (dialysis group), and 40 patients without nephropathy (non-dialysis group). The profile set mean blood glucose was calculated by measuring blood glucose levels seven times a day. The relationship of profile set mean blood glucose with HbAlc and GA levels was then investigated.Corrected HbAlc levels were calculated by applying the profile set mean blood glucose of each ESRD patient to the regression formula for the HbAlc of non-dialysis patients. The actual and corrected HbAlc levels for the predialysis patients were 5.4 +/- 1.1 and 7.9 +/- 1.1%, respectively, while those for the dialysis patients were 5.6 +/- 1.0 and 7.5 +/- 0.9%, respectively (p