Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.
Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.
复制标题
痣计数与色素表型、组织病理学黑色素瘤特征和黑色素瘤存活率相关。
DOI：
10.1002/ijc.30157
复制
发表时间：
2016
影响因子：
6.4
通讯作者：
Z
中科院分区：
文献类型：
--
作者：
Taylor,NicholasJ;Thomas,NancyE;Anton-Culver,Hoda;Armstrong,BruceK;Begg,ColinB;Busam,KlausJ;Cust,AnneE;Dwyer,Terence;From,Lynn;Gallagher,RichardP;Gruber,StephenB;Nishri,DianeE;Orlow,Irene;Rosso,Stefano;Venn,AlisonJ;Z
虽然痣数量是黑色素瘤的一个既定风险因素，但痣数量与患者和肿瘤特征之间的关系尚未得到很好的研究，痣数量对黑色素瘤特异性生存率的影响是不确定的。使用来自基因，环境和黑色素瘤（GEM）研究的数据，这是一项基于人群的原发性皮肤黑色素瘤研究，我们评估了痣数量与患者特征之间的相关性，包括表型指数中总结的阳光敏感性和肿瘤特征。我们还评估了痣计数与黑色素瘤特异性生存率的相关性。较高的痣计数与男性性别和诊断时的年轻年龄独立呈正相关，与恶性雀斑样痣组织学呈负相关。我们观察到随着痣计数的四分位数增加，黑色素瘤特异性生存率下降的边缘显著趋势，但痣数量与色素瘤表型特征或预后肿瘤特征之间几乎没有相关性。
Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma‐specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population‐based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun‐sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma‐specific survival. Higher nevus counts were independently and positively associated with male gender and younger age at diagnosis, and they were inversely associated with lentigo maligna histology. We observed a borderline significant trend of poorer melanoma‐specific survival with increasing quartile of nevus count, but little or no association between number of nevi and pigmentary phenotypic characteristics or prognostic tumor features.