Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma
Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma
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DOI：
10.1111/j.1349-7006.2004.tb02492.x
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发表时间：
2004-07-01
期刊：
影响因子：
5.7
通讯作者：
Tanaka, T
中科院分区：
文献类型：
--
作者：
Yamamoto, S;Kubo, S;Tanaka, T
虽然丙型肝炎病毒（HCV）相关的肝硬化已被认为是肝内胆管癌（ICC）的一个危险因素，很少有相当大的研究已经验证了这一假设。我们调查了ICC的危险因素，特别是HCV感染。我们进行了一项以医院为基础的病例对照研究，包括50名ICC患者和205名其他手术患者，无原发性肝癌。丙型肝炎病毒血清阳性检测36%的ICC患者和3%的控制。通过单变量分析，抗HCV抗体与发展相关的比值比（OR）为16.87（95%置信区间（CI）为5.69至50.00）。输血或糖尿病史、血清总胆红素升高、天冬氨酸转氨酶和丙氨酸转氨酶升高、血清白蛋白降低和血小板计数降低被确定为其他可能的ICC危险因素。通过多变量分析，抗-HCV抗体（调整OR，6.02; 95%CI，1.51至24.1），丙氨酸氨基转移酶升高，血清白蛋白降低，血小板计数减少被认为是独立的危险因素ICC的发展。随着肝脏状态恶化，ICC的调整OR趋于增加。在日本，HCV感染可能是ICC的病因。
Although hepatitis C virus (HCV)-related cirrhosis has been suggested as a risk factor for intrahepatic cholangiocarcinoma (ICC), few sizeable studies have tested this hypothesis. We investigated ICC risk factors, with special reference to HCV infection. We conducted a hospital-based case-control study including 50 ICC patients and 205 other surgical patients without primary liver cancer. HCV seropositivity was detected in 36% of ICC patients and 3% of controls. By univariate analysis, the odds ratio (OR) for association of anti-HCV antibodies with development was 16.87 (95% confidence interval (CI), 5.69 to 50.00). History of blood transfusion or diabetes mellitus, elevated serum total bilirubin, elevated aspartate aminotransferase and alanine aminotransferase, decreased serum albumin and decreased platelet count were identified as other possible ICC risk factors. By multivariate analysis, anti-HCV antibodies (adjusted OR, 6.02; 95% CI, 1.51 to 24.1), elevated alanine aminotransferase, decreased serum albumin, and decreased platelet count were found to be independent risk factors for ICC development. As liver status worsened, the adjusted OR for ICC tended to increase. HCV infection is a likely etiology of ICC in Japan.