Some examples of anomalous radiosensitizing behaviour of electron-affinic compounds in vitro.
Some examples of anomalous radiosensitizing behaviour of electron-affinic compounds in vitro.
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亲电子化合物体外异常放射增敏行为的一些例子。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
R. Jacobs
中科院分区：
文献类型：
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作者：
M. Watts;R. Jacobs
使用V79 379A细胞对约50种硝基芳族和硝基杂环放射增敏剂进行的研究证实了敏化效率和电子亲和力之间的关系。几乎所有研究的化合物都表现相似，通过剂量调整方式使缺氧细胞对 X 射线敏感，同时对含氧细胞没有敏化作用。然而，少数研究的放射增敏剂表现出额外的或非典型的特性。被氯取代的 4-硝基咪唑环使缺氧细胞敏化的效果比根据其氧化还原电位预测的要有效得多。被羧酸侧链取代的 2-硝基咪唑在 5 个浓度范围内表现出较低但恒定的致敏水平。 5-硝基呋喃除了通过剂量调整使缺氧细胞敏感外，还通过减少外推数使含氧细胞敏感。
Studies using V79 379A cells on about 50 nitroaromatic and nitroheterocyclic radisosensitizers have confirmed the relationship between sensitizing efficiency and electron affinity. Almost all the compounds studied behaved similarly by sensitizing hypoxic cells to X-irradiation in a dose-modifying manner whilst having no sensitizing effect on oxygenated cells. However, a small number of the radiosensitizers studied exhibited additional or atypical properties. A 4-nitroimidazole ring substituted with chlorine sensitized hypoxic cells much more efficiently than predicted from its redox potential. A 2-nitroimidazole substituted with a carboxylic acid side chain showed a low but constant level of sensitization over 5 decades of concentration. A 5-nitrofuran, in addition to sensitizing hypoxic cells by dose modification, sensitized oxygenated cells by a reduction in extrapolation number.