Nutrition and HIV infection: Review of weight loss and wasting in the era of highly active antiretroviral therapy from the Nutrition for Healthy Living cohort
Nutrition and HIV infection: Review of weight loss and wasting in the era of highly active antiretroviral therapy from the Nutrition for Healthy Living cohort
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DOI：
10.1086/500398
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发表时间：
2006-03-15
影响因子：
11.8
通讯作者：
Wanke, CA
中科院分区：
文献类型：
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作者：
Mangili, A;Murman, DH;Wanke, CA
尽管在人类免疫缺陷病毒（HIV）感染患者的治疗和生存方面取得了重大进展，但体重减轻和消瘦仍然是常见问题。在 HIV 感染人群中，体重减轻与 CD4(+) 细胞计数降低有关，并且是死亡率的独立预测因素。体重减轻和消瘦的病因是复杂且多因素的。我们在检查艾滋病毒感染者营养状况的大型纵向队列的基础上，讨论了当前临床时代的体重减轻和消瘦数据。总结了 HIV 相关体重减轻和消瘦的定义、患病率和意义。体重减轻的病因主要分为两大类：营养摄入不足和新陈代谢改变。最后，讨论了治疗艾滋病相关体重减轻和消瘦的干预措施的研究。该信息旨在提高 HIV 感染患者的医疗保健提供者的认识，即尽管出现了高效抗逆转录病毒治疗 (HAART)，但体重减轻和消瘦仍然是重要的获得性免疫缺陷综合征定义病症。
Despite major advances in the treatment and survival of patients infected with human immunodeficiency virus (HIV), weight loss and wasting remain common problems. In the HIV-infected population, weight loss is associated with lower CD4(+) cell counts and is an independent predictor of mortality. The etiology of weight loss and wasting is complex and multifactorial. We discuss, on the basis of a large longitudinal cohort that examined nutritional status in HIV infection, data on weight loss and wasting from the present clinical era. The definition, prevalence, and significance of HIV-associated weight loss and wasting are summarized. The etiology of weight loss is discussed for 2 main categories: inadequate nutrient intake and altered metabolism. Finally, studies of interventions to treat HIV-associated weight loss and wasting are discussed. This information is intended to raise awareness among health care providers of HIV-infected patients that weight loss and wasting remain important acquired immunodeficiency syndrome-defining conditions, despite the advent of HAART.