Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at 1 year in women living with human immunodeficiency virus: a prospective cohort study.
Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at 1 year in women living with human immunodeficiency virus: a prospective cohort study.
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DOI：
10.1111/1471-0528.16758
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Ramogola-Masire D
中科院分区：
文献类型：
--
作者：
Luckett R;Painter H;Hacker MR;Simon B;Seiphetlheng A;Erlinger A;Eakin C;Moyo S;Kyokunda LT;Esselen K;Feldman S;Morroni C;Ramogola-Masire D
Evaluate one-year outcomes of cervical cancer screening and treatment using primary high-risk human papillomavirus (HPV) testing in women living with human immunodeficiency virus (HIV). Prospective cohort study HIV treatment center in Botswana Women living with HIV Participants underwent cervical cancer screening with high-risk HPV testing and triage evaluation at baseline and one-year follow-up. Excisional treatment was offered as indicated. Histopathology was the gold standard. Persistence, clearance and incidence of high-risk HPV infection; and persistence, progression, regression, cure and incidence of cervical dysplasia. Among 300 women screened at baseline, 237 attended follow-up (79%). High-risk HPV positivity significantly reduced from 28% at baseline to 20% at one year (p=0.02). High-risk HPV persistence was 46% and clearance 54%; incidence was high at 9%. Prevalence of cervical intraepithelial neoplasia grade (CIN) 2 or higher was most common in participants with incident high-risk HPV (53%). CIN2 or higher was also common in those with persistent high-risk HPV (32%) and even in those who cleared high-risk HPV (30%). 40% of high-risk HPV positive participants at baseline with <CIN2 progressed to CIN2 or higher at follow-up. The high incidence of high-risk HPV and high-grade cervical dysplasia in women living with HIV after one round of high-risk HPV-based screening and treatment raises concern about the rate of progression of high-risk HPV infection to dysplasia. Persistent disease is common. Caution in spacing cervical cancer screening intervals using high-risk HPV testing in women living with HIV is warranted. High incidence and persistence of HPV and CIN2+ in women living with HIV one year after screening and treatment.
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DOI：
10.1097/qad.0000000000001765
发表时间：
2018-03-27
期刊：
AIDS (London, England)
影响因子：
--
作者：
Liu G;Sharma M;Tan N;Barnabas RV
通讯作者：
Barnabas RV
影响因子：
3.7
作者：
Firnhaber, Cynthia;Goeieman, Bridgette;Smith, Jennifer S.
通讯作者：
Smith, Jennifer S.
影响因子：
7.2
作者：
Luckett, Rebecca;Mogowa, Neo;Ramogola-Masire, Doreen
通讯作者：
Ramogola-Masire, Doreen
影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
3.7
作者：
Castle, Philip E.;Varallo, John E.;Rammipi, Kereng
通讯作者：
Rammipi, Kereng