ASSOCIATION OF IOTA-LIKE TOXIN AND CLOSTRIDIUM-SPIROFORME WITH BOTH SPONTANEOUS AND ANTIBIOTIC-ASSOCIATED DIARRHEA AND COLITIS IN RABBITS
ASSOCIATION OF IOTA-LIKE TOXIN AND CLOSTRIDIUM-SPIROFORME WITH BOTH SPONTANEOUS AND ANTIBIOTIC-ASSOCIATED DIARRHEA AND COLITIS IN RABBITS
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DOI：
10.1128/jcm.17.3.414-418.1983
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发表时间：
1983-01-01
影响因子：
9.4
通讯作者：
CARMAN, RJ
中科院分区：
文献类型：
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作者：
BORRIELLO, SP;CARMAN, RJ
一种螺旋卷曲的厌氧革兰氏阳性芽孢杆菌，鉴定为C。从27只自发性腹泻家兔的盲肠内容物中分离出螺旋体，平均浓度为106.0孢子/g材料。所有这些兔子的盲肠内容物中都有毒素，该毒素被抗C中和。产气荚膜杆菌E型毒素，但不被其他梭菌抗毒素所抑制。4只克林霉素相关性结肠炎家兔C.平均浓度为104.5。所有这些动物均存在iota样毒素。在72只健康动物盲肠内容物中未检测到类I毒素;在这些动物中的2只中发现螺形菌，平均浓度为106.0。C. spiroforme在体外产生一种毒素，对小鼠是致命的，并导致豚鼠皮肤坏死。在所有情况下，这种毒素都被抗C中和。产气荚膜杆菌E型毒素。
A helically coiled, anaerobic, gram-positive sporeforming bacillus, identified as C. spiroforme, was isolated from the cecal contents of 27 rabbits with spontaneous diarrhea, at a mean concentration of 106.0 spores/g of material. All of these rabbits had a toxin present in their cecal contents that was neutralized by anti-C. perfringens type E iota toxin, but not by other clostridial antitoxins. Four rabbits with clindamycin-associated colitis were positive for C. spiroforme at a mean concentration of 104.5. All of these animals had iota-like toxin present. Iota-like toxin was not detected in the cecal contents of 72 healthy animals; C. spiroforme was found in 2 of these animals at a mean concentration of 106.0. C. spiroforme produced a toxin in vitro that was lethal to mice and caused dermonecrosis in guinea pigs. In all cases, this toxin was neutralized by anti-C. perfringens type E iota toxin.