Effect of chemotherapy combined with caffeine for osteosarcoma
Effect of chemotherapy combined with caffeine for osteosarcoma
复制标题
化疗联合咖啡因治疗骨肉瘤的疗效
DOI：
10.1007/bf01211797
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发表时间：
2005
影响因子：
3.6
通讯作者：
K. Tomita
中科院分区：
文献类型：
--
作者：
H. Tsuchiya;H. Yasutake;A. Yokogawa;H. Baba;Y. Ueda;K. Tomita
九名骨肉瘤患者接受了化疗加咖啡因和手术治疗。所有原发性肿瘤均显示出对术前化疗的完全组织学反应，化疗包括三次动脉内输注顺铂和咖啡因（不加/加阿霉素）以及两次全身大剂量甲氨蝶呤联合长春新碱。对8名边缘手术患者进行了保肢手术，保留了良好的肢体功能。一名跟骨骨肉瘤患者接受了膝下截肢术。 7 名传统骨肉瘤患者在中位随访 28 个月内未出现局部复发或肺转移。尽管术前化疗完全破坏了原发肿瘤，但在一名小细胞骨肉瘤患者中观察到导致死亡的肺转移。化疗联合咖啡因治疗骨肉瘤值得进一步广泛和大规模的研究。
Nine patients with osteosarcoma were treated by chemotherapy combined with caffeine and surgery. All primary tumors showed complete histological response to preoperative chemotherapy consisting of three intraarterial infusions of cisplatin and caffeine without/with doxorubicin and two systemic high-dose methotrexate combined with vincristine. Limb-salvage surgery was performed in eight patients with marginal procedure, which led to the preservation of good limb function. Below-knee amputation was done in one patient with calcaneal osteosarcoma. There has been neither local recurrence nor lung metastasis in seven patients with conventional osteosarcoma during a median follow-up period of 28 months. Lung metastases leading to death were observed in one patient with small-cell osteosarcoma despite complete destruction of the primary tumor by preoperative chemotherapy. Chemotherapy combined with caffeine administration deserves further extensive and large-scale study in osteosarcoma.