SERUM IGG, IGA, AND IGM RESPONSES TO PERTUSSIS TOXIN, FILAMENTOUS HEMAGGLUTININ, AND AGGLUTINOGEN-2 AND AGGLUTINOGEN-3 AFTER INFECTION WITH BORDETELLA-PERTUSSIS AND IMMUNIZATION WITH WHOLE-CELL PERTUSSIS-VACCINE
SERUM IGG, IGA, AND IGM RESPONSES TO PERTUSSIS TOXIN, FILAMENTOUS HEMAGGLUTININ, AND AGGLUTINOGEN-2 AND AGGLUTINOGEN-3 AFTER INFECTION WITH BORDETELLA-PERTUSSIS AND IMMUNIZATION WITH WHOLE-CELL PERTUSSIS-VACCINE
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DOI：
10.1093/infdis/160.5.838
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发表时间：
1989-11-01
影响因子：
6.4
通讯作者：
LAMBERT, HP
中科院分区：
文献类型：
--
作者：
THOMAS, MG;ASHWORTH, LAE;LAMBERT, HP
研究了114例百日咳患者、49例百日咳患者家庭接触者和139例参加疫苗接种的婴儿对百日咳毒素（PT）、丝状血凝素（FHA）、凝集素2和3 （Agg 2/3）的类抗体反应。IgG对FHA和PT的反应在百日咳患者和接种三次全细胞百日咳疫苗的婴儿中相似。百日咳患者的IgA对FHA和PT的反应大于疫苗接种者，血清IgA对PT的log10滴度bb1.9是百日咳感染的有效鉴别指标。与百日咳患者相比，接种疫苗者对Agg 2/3有更大的IgG反应，对Agg 2/3有相当的IgA反应。FHA、PT和Agg 2/3的血清学反应在家庭接触者中很常见，但小于百日咳患者的反应。3 ~ 10岁家庭接触者对FHA的IgG和IgA初始滴度显著高于同年龄组百日咳患者（P < 0.005和P < 0.05）。
Class antibody responses to pertussis toxin (PT), filamentous hemagglutinin (FHA), and agglutinogens 2 and 3 (Agg 2/3) were studied in 114 patients with pertussis, 49 family contacts of patients with pertussis, and 139 infants attending vaccination clinics. IgG resposes to FHA and PT were similar in patients with pertussis and in infants immunized three times with whole-cell pertussis vaccine. IgA responses to FHA an PT were greater in patients with pertussis than in vaccinees, and a serum log10 titer of IgA to PT > 1.9 was a usefuldiscriminant of Bordetella pertussis infection. When compared with patients with pertussis vaccinees had a greater IgG response to Agg 2/3 and an equivalent IgA response to Agg 2/3. Serologic responses to FHA, PT, and Agg 2/3 were common in family contacts but were smaller than the responses in patients with pertussis. Initial titers of IgG to FHA and IgA to FHA were significantly higher (P < .005 and P < .05, respectively) in family contacts aged 3-10 y than in patients with pertussis in an identical age group.